Insulin-like growth factor binding protein-1 regulates HIF-1α degradation to inhibit apoptosis in hypoxic cardiomyocytes
| العنوان: | Insulin-like growth factor binding protein-1 regulates HIF-1α degradation to inhibit apoptosis in hypoxic cardiomyocytes |
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| المؤلفون: | Huilin Jiang, Yongcheng Zhu, Xiaohui Chen, Xiaoyan Tang, Yi Zhang, Ningning Liu, Pei-Yi Lin, Meiting Chen, Zhen-hui Zhang, Junrong Mo |
| المصدر: | Cell Death Discovery Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_treatment, Immunology, Article, Protein expression, Insulin-like growth factor-binding protein, Cellular and Molecular Neuroscience, medicine, Myocardial infarction, RC254-282, QH573-671, biology, Chemistry, Growth factor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell Biology, Translational research, Hypoxia (medical), medicine.disease, Cell biology, Apoptosis, biology.protein, medicine.symptom, Cytology, Ischemic heart, hormones, hormone substitutes, and hormone antagonists, Function (biology) |
| الوصف: | Hypoxia is important in ischemic heart disease. Excessive Insulin-like growth factor binding protein-1 (IGFBP-1) amounts are considered to harm cardiomyocytes in acute myocardial infarction. However, the mechanisms by which IGFBP-1 affects cardiomyocytes remain undefined. The present study demonstrated that hypoxia up-regulates IGFBP-1 and HIF-1α protein expression in cardiomyocytes. Subsequent assays showed that IGFBP-1 suppression decreased HIF-1α expression and inhibited hypoxia-induced apoptosis in cardiomyocytes, which was reversed by HIF-1α overexpression, indicating that HIF-1α is essential to IGFBP-1 function in cellular apoptosis. In addition, we showed that IGFBP-1 regulated HIF-1α stabilization through interacting with VHL. The present findings suggest that IGFBP-1–HIF-1α could be targeted for treating ischemic heart disease. |
| تدمد: | 2058-7716 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c0eb6fa6418606ced2af903d8927ed https://doi.org/10.1038/s41420-021-00629-3 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f1c0eb6fa6418606ced2af903d8927ed |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20587716 |
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