Catalytic Asymmetric Total Synthesis of Leucinostatin A
| العنوان: | Catalytic Asymmetric Total Synthesis of Leucinostatin A |
|---|---|
| المؤلفون: | Takumi Watanabe, Masakatsu Shibasaki, Hikaru Abe |
| المصدر: | The Chemical Record. 21:175-187 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 010405 organic chemistry, Stereochemistry, Chemistry, General Chemical Engineering, Absolute configuration, Total synthesis, Antineoplastic Agents, Stereoisomerism, General Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, 0104 chemical sciences, Residue (chemistry), Cell Line, Tumor, Materials Chemistry, Side chain, Humans, Structure–activity relationship, Stereoselectivity, Leucinostatin, Antimicrobial Cationic Peptides |
| الوصف: | This review describes our efforts toward achieving catalytic asymmetric total synthesis of leucinostatin A, a compound that interferes with the tumor-stroma interaction. The synthesis utilizes four catalytic asymmetric reactions, including direct-type reactions exemplified by high atom-economy, and three C-C bond forming reactions. Thorough analysis of the NMR data, HPLC profiles, and biologic activity led us to unambiguously revise the absolute configuration regarding the 6-position of the AHMOD residue side chain from S (reported) to R. Other examples of previously reported important studies on the stereoselective synthesis of HyLeu and AHMOD are also described. |
| تدمد: | 1528-0691 1527-8999 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f0b176abb8ec40aff0185c7a8e1374 https://doi.org/10.1002/tcr.202000108 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f1f0b176abb8ec40aff0185c7a8e1374 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280691 15278999 |
|---|