Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression
| العنوان: | Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression |
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| المؤلفون: | Shuang, Liu, Man, Liu, Meng-Lin, Zhang, Cui-Zhe, Wang, Yin-Liang, Zhang, Yu-Jie, Zhang, Chun-Yuan, Du, Su-Fang, Sheng, Wei, Wang, Ya-Tong, Fan, Jia-Ni, Song, Jin-Can, Huang, Yue-Yao, Feng, Wei, Qiao, Jin-Long, Huang, Yu-Hui, Li, Lu, Zhou, Jun, Zhang, Yong-Sheng, Chang |
| المصدر: | Acta Pharmacologica Sinica. 43:2362-2372 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology, Symporters, Kruppel-Like Transcription Factors, Organic Anion Transporters, Sodium-Dependent, General Medicine, Bile Acids and Salts, Intestines, Mice, Inbred C57BL, Mice, Liver, Enterohepatic Circulation, Animals, Pharmacology (medical), Transcription Factors |
| الوصف: | Bile acid (BA) homeostasis is regulated by the extensive cross-talk between liver and intestine. Many bile-acid-activated signaling pathways have become attractive therapeutic targets for the treatment of metabolic disorders. In this study we investigated the regulatory mechanisms of BA in the intestine. We showed that the BA levels in the gallbladder and faeces were significantly increased, whereas serum BA levels decreased in systemic Krüppel-like factor 9 (Klf9) deficiency (Klf9 |
| تدمد: | 1745-7254 1671-4083 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f208f8e9520748f71d4c51d7af1249b7 https://doi.org/10.1038/s41401-021-00850-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f208f8e9520748f71d4c51d7af1249b7 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17457254 16714083 |
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