Case series of probable sporadic Creutzfeldt-Jakob disease from Eastern India
| العنوان: | Case series of probable sporadic Creutzfeldt-Jakob disease from Eastern India |
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| المؤلفون: | Namrata Khandelwal, Alak Pandit, Arijit Roy, Goutam Gangopadhyay, Asit Kumar Senapati, Atanu Biswas, Deb Sankar Guin |
| المصدر: | Annals of Indian Academy of Neurology Annals of Indian Academy of Neurology, Vol 16, Iss 4, Pp 659-663 (2013) |
| بيانات النشر: | Medknow Publications & Media Pvt Ltd, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Series (stratigraphy), Pediatrics, medicine.medical_specialty, Pathology, Neurology, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Autopsy, Disease, Electroencephalography, medicine.disease, Eastern india, lcsh:RC346-429, Creutzfeldt-Jakob disease, medicine, Dementia, magnetic resonance imaging, Original Article, Neurology (clinical), business, lcsh:Neurology. Diseases of the nervous system, electroencephalography |
| الوصف: | Background: Creutzfeldt-Jakob disease is a rapidly progressive, fatal, transmissible neurodegenerative disorder caused by prion protein. It is still considered rare in countries like India. This is probably due to nonavailability of autopsy studies in majority of the center. The recent European diagnostic criterion for sporadic CJD (sCJD) is useful for making an early diagnosis. Objective: To report a series of patients of probable sCJD from a neurology institute of eastern India. Materials and Methods: Patients of rapidly developing dementia fulfilling the diagnostic criteria for sCJD were included. All were investigated in detail to find out any possible treatable cause including electroencephalography (EEG), magnetic resonance imaging (MRI) of brain, and cerebrospinal fluid analysis. Results: A total 10 patients of probable sCJD diagnosed using the European diagnostic criterion between December 2011 and January 2013. The clinical features are consistent with other reported series. While 60% of patients had the classical EEG findings, 100% had typical MRI features. Eight patients died within a mean duration of 4.56 months from the disease onset. Conclusions: The clinical features are similar to other reported series. Our observation raises question about the prevalence of this disease in India which needs more elaborate studies. |
| اللغة: | English |
| تدمد: | 1998-3549 0972-2327 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2145a2b503065e2108a4c5b6fbcfd19 http://europepmc.org/articles/PMC3841621 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f2145a2b503065e2108a4c5b6fbcfd19 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19983549 09722327 |
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