The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer
| العنوان: | The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer |
|---|---|
| المؤلفون: | Ruanmin Zou, Zhiwei Wang, Jing Wang, Xueqiong Zhu, Yichi Xu |
| المصدر: | Cell Proliferation |
| بيانات النشر: | John Wiley and Sons Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Carcinogenesis, medicine.medical_treatment, proliferation, Reviews, Review, medicine.disease_cause, Metastasis, 03 medical and health sciences, 0302 clinical medicine, oncogene, Antigens, Neoplasm, PRAME, Neoplasms, medicine, Animals, Humans, Cell Proliferation, Oncogene, business.industry, Melanoma, Cancer, Cell Biology, General Medicine, Immunotherapy, medicine.disease, tumorigenesis, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Cancer/testis antigens, business |
| الوصف: | Preferentially expressed antigen in melanoma (PRAME), which belongs to the cancer/testis antigen (CTA) gene family, plays a pivotal role in multiple cellular processes and immunotherapy response in human cancers. PRAME is highly expressed in different types of cancers and is involved in cell proliferation, apoptosis, differentiation and metastasis as well as the outcomes of patients with cancer. In this review article, we discuss the potential roles and physiological functions of PRAME in various types of cancers. Moreover, this review highlights immunotherapeutic strategies that target PRAME in human malignancies. Therefore, the modulation of PRAME might be useful for the treatment of patients with cancer. |
| اللغة: | English |
| تدمد: | 1365-2184 0960-7722 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2229efe61878292c186f80c026e1197 http://europepmc.org/articles/PMC7106952 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f2229efe61878292c186f80c026e1197 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652184 09607722 |
|---|