Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats
| العنوان: | Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats |
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| المؤلفون: | Régis Gemerasca Mestriner, Fabrício do Couto Nicola, Viviane Rostirola Elsner, Mayara Ferraz de Menezes, Carlos Alexandre Netto, Adriana Fernanda Kuckartz Vizuete, Ivy Reichert Vital da Silva, Léder Leal Xavier, Carlos Alberto Gonçalves |
| المصدر: | Neural Regeneration Research Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| بيانات النشر: | Medknow Publications & Media Pvt Ltd, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Astrócitos, Central nervous system, Spinal cord injury, Biology, Glial fibrillary acidic protein, Histone H4, Histones, 03 medical and health sciences, recovery, 0302 clinical medicine, astrocyte, Developmental Neuroscience, Histonas, Recovery, Internal medicine, histones, medicine, Medula espinal, Epigenetics, Proteína glial fibrilar ácida, Neural plasticity, ELISA-immunoassay, medicine.disease, Proteínas S100, spinal cord injury, Rats, rats, 030104 developmental biology, Histone, medicine.anatomical_structure, Endocrinology, Acetylation, glial fibrillary acidic protein, biology.protein, neural repair, S100 calcium-binding protein B, Astrocyte, 030217 neurology & neurosurgery, Neural repair, Research Article, neural plasticity |
| الوصف: | Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity - a well-known process that markedly influences the tissue remodeling after a central nervous system injury - is crucial for tissue remodeling after spinal cord injury (SCI). However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood. We sought to investigate the relation between both glial fibrillary acidic protein (GFAP) and S100 calcium-binding protein B (S100B) (astrocytic reactivity classical markers) and global histone H4 acetylation levels. Sixty-one male Wistar rats (aged ~3 months) were divided into the following groups: sham; 6 hours post-SCI; 24 hours post-SCI; 48 hours post-SCI; 72 hours post-SCI; and 7 days post-SCI. The results suggested that GFAP, but not S100B was associated with global histone H4 acetylation levels. Moreover, global histone H4 acetylation levels exhibited a complex pattern after SCI, encompassing at least three clearly defined phases ( first phase: no changes in the 6, 24 and 48 hours post-SCI groups; second phase: increased levels in the 72 hours post-SCI group; and a third phase: return to levels similar to control in the 7 days post-SCI group). Overall, these findings suggest global H4 acetylation levels exhibit distinct patterns of expression during the first week post-SCI, which may be associated with GFAP levels in the perilesional tissue. Current data encourage studies using H4 acetylation as a possible biomarker for tissue remodeling after spinal cord injury. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1876-7958 1673-5374 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23bce40b0bfacedcc6bde03ffc4bab8 http://europepmc.org/articles/PMC6183034 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f23bce40b0bfacedcc6bde03ffc4bab8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18767958 16735374 |
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