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Traffic pollution exposure is associated with altered brain connectivity in school children

التفاصيل البيبلوغرافية
العنوان: Traffic pollution exposure is associated with altered brain connectivity in school children
المؤلفون: Joan Forns, Gerard Martínez-Vilavella, Dídac Macià, Mar Alvarez-Pedrerol, Xavier Querol, Ioar Rivas, Jordi Sunyer, Raquel Fenoll, Joan Deus, Jesús Pujol, Laura Blanco-Hinojo, Jaume Capellades
المصدر: Recercat. Dipósit de la Recerca de Catalunya
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بيانات النشر: Elsevier BV, 2016.
سنة النشر: 2016
مصطلحات موضوعية: Male, Pollution, Magnetic Resonance Spectroscopy, cvg.game_series, Cognitive Neuroscience, media_common.quotation_subject, Infants -- Desenvolupament, Sensory system, 010501 environmental sciences, Affect (psychology), 01 natural sciences, 03 medical and health sciences, Cognition, 0302 clinical medicine, Air Pollution, Image Interpretation, Computer-Assisted, Neural Pathways, 11. Sustainability, Humans, Medicine, Effects of sleep deprivation on cognitive performance, cvg, Child, Default mode network, Vehicle Emissions, 0105 earth and related environmental sciences, media_common, Pollutant, Functional integration (neurobiology), business.industry, Aire -- Contaminació, Brain, Magnetic Resonance Imaging, Neurology, Neural tract, Female, business, Neuroscience, 030217 neurology & neurosurgery
الوصف: Children are more vulnerable to the effects of environmental elements due to their active developmental processes. Exposure to urban air pollution has been associated with poorer cognitive performance, which is thought to be a result of direct interference with brain maturation. We aimed to assess the extent of such potential effects of urban pollution on child brain maturation using general indicators of vehicle exhaust measured in the school environment and a comprehensive imaging evaluation. A group of 263 children, aged 8 to 12years, underwent MRI to quantify regional brain volumes, tissue composition, myelination, cortical thickness, neural tract architecture, membrane metabolites, functional connectivity in major neural networks and activation/deactivation dynamics during a sensory task. A combined measurement of elemental carbon and NO2 was used as a putative marker of vehicle exhaust. Air pollution exposure was associated with brain changes of a functional nature, with no evident effect on brain anatomy, structure or membrane metabolites. Specifically, a higher content of pollutants was associated with lower functional integration and segregation in key brain networks relevant to both inner mental processes (the default mode network) and stimulus-driven mental operations. Age and performance (motor response speed) both showed the opposite effect to that of pollution, thus indicating that higher exposure is associated with slower brain maturation. In conclusion, urban air pollution appears to adversely affect brain maturation in a critical age with changes specifically concerning the functional domain. This work was supported by the European Research Council under the ERC [grant number 268479]—the BREATHE project. The Agency of University and Research Funding Management of the Catalonia Government participated in the context of Research Group SGR2014-1673.
وصف الملف: application/pdf
تدمد: 1053-8119
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2497f9c30a87af3a7a329c1c139b91c
https://doi.org/10.1016/j.neuroimage.2016.01.036
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....f2497f9c30a87af3a7a329c1c139b91c
قاعدة البيانات: OpenAIRE
الوصف
تدمد:10538119