Studies on the Dutch Rabbit for Pyrogen Test
| العنوان: | Studies on the Dutch Rabbit for Pyrogen Test |
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| المؤلفون: | Makoto Ema, Seizaburo Kanoh, Takafumi Itami |
| المصدر: | Experimental Animals. 32:71-76 |
| بيانات النشر: | Japanese Association for Laboratory Animal Science, 1983. |
| سنة النشر: | 1983 |
| مصطلحات موضوعية: | Lipopolysaccharides, Male, General Veterinary, biology, Pyrogens, business.industry, biology.animal_breed, Age Factors, Bacterial Pyrogen, Food consumption, Physiology, General Medicine, Japanese white rabbit, Dutch rabbit, General Biochemistry, Genetics and Molecular Biology, Body Temperature, Species Specificity, JAPANESE WHITE, Animals, Medicine, Female, Animal Science and Zoology, Rabbits, business |
| الوصف: | A study was conducted on Dutch rabbits to examine their applicability for the pyrogen test in comparison with the Japanese white rabbit which, conventionally, has been mainly used for the test in Japan. The following results were obtained. Adult Dutch rabbits, so small as to weight only about 60% of average adult weight of the Japanese white, showed a food consumption as low as 40% of that in the latter. None in the Dutch rabbit group suffered dislocation of the hip-joint during restraint on a neck stock while it was frequently encountered among Japanese white rabbits. The body temperature during restraint was unstable in infantile Dutch rabbits (7-8 weeks old)(, but stable in the young (14 weeks old) and in the adult (20-47 weeks old). Adult Dutch rabbits exhibited greater febrile responses to intravenously injected bacterial pyrogen (LPS) than infantile and young Dutch rabbits and adult Japanese white rabbits. A good linear regression was observed between the dose of LPS (0.01-0.1 microgram/kg, iv) and the febrile response in adult Dutch rabbits as well as in adult Japanese white rabbits. From these data, it is concluded that the Dutch rabbit has an advantage over the Japanese white for the pyrogen test in respect of febrile responsiveness and cost of rearing. |
| تدمد: | 1881-7122 0007-5124 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e8f55f6d36aeeccfd84fb79d9c395b https://doi.org/10.1538/expanim1978.32.2_71 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f2e8f55f6d36aeeccfd84fb79d9c395b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18817122 00075124 |
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