MicroRNA-4491 enhances cell proliferation and inhibits cell apoptosis in non-small cell lung cancer via targeting TRIM7
| العنوان: | MicroRNA-4491 enhances cell proliferation and inhibits cell apoptosis in non-small cell lung cancer via targeting TRIM7 |
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| المؤلفون: | Bo Li, Fei Han, Hanji Tian, Xinfei Zhao, Yi Guo, Yanlong Sun, Xiangqian Qi, Hongguang Zhang, Gang Chen |
| المصدر: | Oncology Letters |
| بيانات النشر: | D.A. Spandidos, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Tumor suppressor gene, Cell, Biology, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, microRNA, medicine, Gene silencing, neoplasms, non-small cell lung cancer, Oncogene, cell apoptosis, Cell growth, miR-4491, Articles, Cell cycle, respiratory tract diseases, tripartite motif containing 7, 030104 developmental biology, medicine.anatomical_structure, cell proliferation, Oncology, 030220 oncology & carcinogenesis, Cancer research |
| الوصف: | MicroRNAs (miRNAs) are involved in the development of non-small cell lung cancer (NSCLC). However, the biological roles of several aberrantly expressed miRNAs have not been explored yet. In the present study, miR-4491 was identified as a novel upregulated miRNA in NSCLC tissues and cell lines. Downregulation of miR-4491 by a miR-4491 inhibitor inhibited the proliferation and triggered the apoptosis of NSCLC cells. Tripartite motif containing 7 (TRIM7), a tumor suppressor gene expressed in NSCLC, was demonstrated in the present study to be directly targeted by miR-4491. This finding was verified by bioinformatics analysis, reverse transcription-quantitative PCR, western blotting and dual luciferase reporter assays. Furthermore, downregulation of miR-4491 inactivated nuclear factor-κB signaling via induction of TRIM7. In addition, TRIM7 silencing attenuated the effect of miR-4491 inhibitor in NSCLC cells. The decreased TRIM7 level in NSCLC tissues was negatively correlated with miR-4491 expression in NSCLC tissues. In conclusion, the findings from this study demonstrated that miR-4491 expression was upregulated in NSCLC tissues and cells and that miR-4491 may promote NSCLC progression via targeting TRIM7. |
| اللغة: | English |
| تدمد: | 1792-1082 1792-1074 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2edcbd9d8f7d89e5210d9d36b8de3ca http://europepmc.org/articles/PMC8200940 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f2edcbd9d8f7d89e5210d9d36b8de3ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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