MicroRNAs related to cholesterol metabolism affected by vegetable diet in rainbow trout (Oncorhynchus mykiss) from control and selected lines
| العنوان: | MicroRNAs related to cholesterol metabolism affected by vegetable diet in rainbow trout (Oncorhynchus mykiss) from control and selected lines |
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| المؤلفون: | Mathilde Dupont-Nivet, Sandrine Skiba-Cassy, Jérôme Montfort, Edwige Quillet, Tengfei Zhu, Geneviève Corraze, Elisabeth Plagnes-Juan, Julien Bobe |
| المساهمون: | Nutrition, Métabolisme, Aquaculture (NuMéA), Institut National de la Recherche Agronomique (INRA)-Université de Pau et des Pays de l'Adour (UPPA), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Recherche Agronomique (INRA), Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, ANR-13-ADAP-001 AGREENFISH, Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), This work was carried out within the framework of the AGREENFISH project (project ANR-13-ADAP-001) funded by the French National Research Agency (ANR). T. Zhu gratefully acknowledges the financial assistance provided by the China Scholarship Council (CSC, File No. 201406330071) for his doctoral fellowship., ANR-13-ADAP-0001,AGREENFISH,Adaptations aux transitions alimentaires en aquaculture: les caractériser et les favoriser(2013) |
| المصدر: | Aquaculture Aquaculture, Elsevier, 2019, 498, pp.132-142. ⟨10.1016/j.aquaculture.2018.08.058⟩ |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | food intake, [SDV]Life Sciences [q-bio], adaptation, poisson, Aquaculture, salmonids, lipid metabolism, Food science, adaptation alimentaire, métabolisme du cholestérol, salmonidae, trout, alimentation, oncorhynchus mykiss, 0303 health sciences, biology, 04 agricultural and veterinary sciences, foie, Fish oil, rainbow trout, microRNAs, régime alimentaire, Trout, micro arn, expression des gènes, Aquatic Science, Selective breeding, 03 medical and health sciences, Fish meal, rainbow, transcription factors, croissance animale, nutrition animale, signal de transduction, 14. Life underwater, Salmonidae, 030304 developmental biology, fish, apoptose, métabolisme lipidique, business.industry, Lipid metabolism, biology.organism_classification, plant-based diet, alimentation végétale, animal nutrition, cholesterol metabolism, 040102 fisheries, 0401 agriculture, forestry, and fisheries, Rainbow trout, liver function tests, business, facteur de transcription, animal growth, truite arc en ciel |
| الوصف: | For the sustainable development of aquaculture, vegetable ingredients have been used to replace the traditional ingredients fishmeal and fish oil in aquafeeds. On the other hand, selective breeding has also been implemented at research level to obtain strains that are adapted to feeding on the plant-based diet. To better understand the underlying mechanisms prompting the adaptation to plant-based diets in fish, we investigated the hepatic expression of several microRNAs (miRNAs) that are involved in the post-transcriptional regulation of cholesterol and lipid metabolism at 8 h and 16 h after the last meal in two lines of rainbow trout: one selected for better adaptation to plant-based diets and the corresponding control line. Both groups were fed either a fishmeal and fish oil based diet or a 100% plant-based diet. Results showed that the expression of miR-33a in liver was greatly elevated in trout fed the plant-based diet, while the expression of miR-122 and miR-128 was much higher in the selected line at 8 h after the last meal regardless of the diet. Furthermore, our results indicated that some genes involved in immune processes (caspase 6 apoptosis-related cysteine peptidase like 2, casp6l2) and cAMP signal transduction (phosphodiesterase 4B cAMP-specific a, pde4ba) were also potentially regulated by miRNAs. They were newly identified as putative direct targets of miRNAs and affected in trout fed the plant-based diet. Though further investigations are still needed to establish a valid relationship between miRNAs and their target genes, our study found miR-33a, miR-122 and miR-128 as potential candidates for further study and provided new perspectives to understand the role of miRNAs in the selective breeding for adaptation to the plant-based diets. |
| تدمد: | 0044-8486 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32404730c23f3123e2e03f35059fd79 https://doi.org/10.1016/j.aquaculture.2018.08.058 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f32404730c23f3123e2e03f35059fd79 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00448486 |
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