Astrogliopathology in the infectious insults of the brain
| العنوان: | Astrogliopathology in the infectious insults of the brain |
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| المؤلفون: | Alexei Verkhratsky, Robert Zorec, Tatjana Avšič Županc |
| المصدر: | Zorec, R, Avšič Županc, T & Verkhratsky, A 2019, ' Astrogliopathology in the infectious insults of the brain ', Neuroscience letters, vol. 689 . https://doi.org/10.1016/j.neulet.2018.08.003 Zorec, R, Županc, T A & Verkhratsky, A 2019, ' Astrogliopathology in the infectious insults of the brain ', Neuroscience Letters, vol. 689, pp. 56-62 . https://doi.org/10.1016/j.neulet.2018.08.003 |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Central nervous system, Neuroinfection, Zika virus, CNS homeostasis, Astroglia, 03 medical and health sciences, Flaviviridae, 0302 clinical medicine, medicine, Animals, Humans, Protozoan Infections, biology, General Neuroscience, Bacterial Infections, biology.organism_classification, medicine.disease, Astrogliosis, 030104 developmental biology, medicine.anatomical_structure, Virus Diseases, Anaerobic glycolysis, Astrocytes, Encephalitis, Neuroglia, Tick-borne encephalitis virus, Neuroscience, 030217 neurology & neurosurgery, Astrocyte |
| الوصف: | Astroglia, a heterogeneous type of neuroglia, play key homeostatic functions in the central nervous system (CNS) and represent an important defence system. Impaired homeostatic capacity of astrocytes manifests in diseases and this is mirrored in various astrocyte-based pathological features including reactive astrogliosis, astrodegeneration with astroglial atrophy and pathological remodelling of astrocytes. All of these manifestations are most prominently associated with infectious insults, mediated by bacteria, protozoa and viruses. Here we focus onto neurotropic viruses such as tick-borne encephalitis (TBEV) and Zika virus (ZIKV), both belonging to Flaviviridae and both causing severe neurological impairments. We argue that astrocytes provide a route through which neurotropic infectious agents attack the CNS, since they are anatomically associated with the blood-brain barrier and exhibit aerobic glycolysis, a metabolic specialisation of highly morphologically dynamic cells, which may provide a suitable metabolic milieu for proliferation of infectious agents, including viral bodies. |
| وصف الملف: | application/pdf |
| تدمد: | 0304-3940 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f324cd9d8f1fcc5edb7dd6a847fd92ec https://doi.org/10.1016/j.neulet.2018.08.003 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f324cd9d8f1fcc5edb7dd6a847fd92ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03043940 |
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