Probabilistic Category Learning and Striatal Functional Activation in Psychosis Risk
| العنوان: | Probabilistic Category Learning and Striatal Functional Activation in Psychosis Risk |
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| المؤلفون: | Jessica P.Y. Hua, Nicole R. Karcher, John G. Kerns |
| المصدر: | Schizophrenia Bulletin. 45:396-404 |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, Risk, Adolescent, Concept Formation, Psychosis risk, Striatum, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Behavioral study, Concept learning, Weather prediction, Humans, Medicine, Cerebral Cortex, Brain Mapping, business.industry, Magnetic Resonance Imaging, Corpus Striatum, 030227 psychiatry, Psychiatry and Mental health, Psychotic Disorders, Female, Probability Learning, business, 030217 neurology & neurosurgery, Regular Articles, Clinical psychology |
| الوصف: | Background Psychosis risk is associated with striatal dysfunction, including a previous behavioral study that found that psychosis risk is associated with impaired performance on a probabilistic category learning task (PCLT; ie, the Weather Prediction Task), a task strongly associated with striatal activation. The current study examined whether psychosis risk based on symptom levels was associated with both poor behavioral performance and task-related physiological dysfunction in specific regions of the striatum while performing the PCLT. Methods There were 2 groups of participants: psychosis risk (n = 21) who had both (a) extreme levels of self-reported psychotic-like beliefs and experiences and (b) interview-rated current attenuated psychotic symptoms (APS); and a comparison group (n = 20) who had average levels of self-reported psychotic-like beliefs and experiences. Participants completed the PCLT during fMRI scanning. Results The current research replicated previous work finding behavioral PCLT deficits at the end of the task in psychosis risk. Furthermore, as expected, the psychosis risk group exhibited decreased striatal activation on the task, especially in the associative striatum. The psychosis risk group also displayed decreased activation in a range of cortical regions connected to the associative striatum. In contrast, the psychosis risk group exhibited greater activation predominantly in cortical regions not connected to the associative striatum. Conclusions Psychosis risk was associated with both behavioral and striatal dysfunction during performance on the PCLT, suggesting that behavioral and imaging measures using this task could be a marker for psychosis risk. |
| تدمد: | 1745-1701 0586-7614 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33b18f108705949c526a72f732405f4 https://doi.org/10.1093/schbul/sby033 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f33b18f108705949c526a72f732405f4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17451701 05867614 |
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