Does Age Matter? Behavioral and Neuro-anatomical Effects of Neonatal and Adult Basal Forebrain Cholinergic Lesions
| العنوان: | Does Age Matter? Behavioral and Neuro-anatomical Effects of Neonatal and Adult Basal Forebrain Cholinergic Lesions |
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| المؤلفون: | Laura Petrosini, Paola De Bartolo, Gemma Calamandrei, Daniela Laricchiuta, Francesca Gelfo, Debora Cutuli, Maria Luisa Scattoni, Laura Ricceri, Francesca Foti |
| المصدر: | Journal of Alzheimer's Disease. 20:207-227 |
| بيانات النشر: | IOS Press, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Aging, 192 igg-saporin, Morris water navigation task, Open field, Discrimination Learning, Basal (phylogenetics), spatial function, pyramidal neurons, alzheimer's disease, age effect, cholinergic lesion, rat, neuronal morphology, Cognitive decline, gamma-Aminobutyric Acid, Neurologic Examination, Neurons, Basal forebrain, Behavior, Animal, Learning Disabilities, General Neuroscience, Age Factors, Antibodies, Monoclonal, Dextrans, General Medicine, Psychiatry and Mental health, Clinical Psychology, Ribosome Inactivating Proteins, Type 1, Psychology, Acetylcholine, medicine.drug, Biotin, Choline O-Acetyltransferase, Prosencephalon, Avoidance Learning, medicine, Animals, Rats, Wistar, Cholinergic neuron, Maze Learning, Analysis of Variance, Saporins, Rats, Disease Models, Animal, Animals, Newborn, Brain Injuries, Exploratory Behavior, Cholinergic, Geriatrics and Gerontology, Neuroscience |
| الوصف: | The "cholinergic hypothesis" of dementia posits that the progressive loss of basal forebrain cholinergic neurons and the consequent decrease of acetylcholine levels in the deafferented projection sites are correlated with degree of cognitive decline in dementia. It has also been proposed that early dysfunction of the basal forebrain (BF) cholinergic system may be a risk factor for subsequent cognitive decline and possibly dementia. To characterize how age when BF cholinergic system is lesioned affects behavioral performances and morphology of neocortical neurons, seven-day-old rats were bilaterally i.c.v. injected with 192 IgG-saporin. In adulthood, these animals were subjected to spatial and associative tests. Subsequently, the morphology of parietal pyramidal neurons was assessed. The same behavioral and morphological evaluations were made in 80-day-old rats tested three weeks after bilateral i.c.v. injections of 192 IgG-saporin. The behavioral consequences of both cholinergic depletions were markedly similar. While both groups of lesioned animals exhibited very subtle deficits in the Morris water maze, they were significantly impaired in spatial discrimination in the open field and the radial maze. Paralleling behavioral data, the results of the morphological analysis revealed comparable increases in number and density of spines in apical and basal dendrites in layer-III parietal pyramidal neurons following both neonatal and adult cholinergic depletions. The present results demonstrate that the consequences of abnormal maturation of the cholinergic system are not substantially different from those evoked by cholinergic dysfunction in adulthood and provide a developmental psychobiological perspective of the neuronal foundations of the impaired cognitive functions. |
| تدمد: | 1875-8908 1387-2877 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3dd86ec28533116e3a354bfb982db8d https://doi.org/10.3233/jad-2010-1355 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f3dd86ec28533116e3a354bfb982db8d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758908 13872877 |
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