Two-Year and Lifetime Toxicity and Carcinogenicity Studies of Ozone in B6C3F1 Mice
| العنوان: | Two-Year and Lifetime Toxicity and Carcinogenicity Studies of Ozone in B6C3F1 Mice |
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| المؤلفون: | Thomas J. Goehl, Ron Herbert, James R. Hailey, Rodney A. Miller, Joseph H. Roycroft, Billy J. Chou, Robert C. Sills, Gary A. Boorman, Sondra L. Grumbein, Joseph K. Haseman |
| المصدر: | Toxicologic Pathology. 24:539-548 |
| بيانات النشر: | SAGE Publications, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Male, Nasal cavity, Pathology, medicine.medical_specialty, Lung Neoplasms, Time Factors, Carcinogenicity Tests, 040301 veterinary sciences, Toxicology, 030226 pharmacology & pharmacy, Pathology and Forensic Medicine, 0403 veterinary science, Mice, 03 medical and health sciences, Ozone, 0302 clinical medicine, Metaplasia, Administration, Inhalation, Toxicity Tests, medicine, Animals, Molecular Biology, Inhalation exposure, Mice, Inbred C3H, Lung, business.industry, Respiratory disease, 04 agricultural and veterinary sciences, Cell Biology, respiratory system, medicine.disease, Squamous metaplasia, Mice, Inbred C57BL, medicine.anatomical_structure, Respiratory epithelium, Female, medicine.symptom, business, Respiratory tract |
| الوصف: | To evaluate the toxicity and carcinogenic potential of long-term exposure to ozone, B6C3F1 mice were exposed by whole-body inhalation to 0, 0.12, 0.5, or 1.0 ppm and 0, 0.5, or 1.0 ppm ozone for 24 or 30 mo (lifetime), respectively. The incidence of alveolar/ bronchiolar adenomas and carcinomas (combined) increased (p < 0.05) in female mice exposed to 1.0 ppm for 24 or 30 mo and marginally increased (p > 0.05) in male mice exposed to concentrations of 0.5 or 1.0 ppm. An increased incidence of nonneoplastic lesions were observed in the nasal cavities and in the centriacinar region of the lung of mice exposed to 0.5 or 1.0 ppm for 24 and 30 mo. Nasal cavity lesions were mild and included hyaline degeneration, hyperplasia, squamous metaplasia, fibrosis and suppurative inflammation of the transitional and respiratory epithelium of the lateral wall, and atrophy of the olfactory epithelium. Lung lesions included replacement of the epithelium of the alveolar ducts and adjacent alveolar septa with epithelium similar to that normally found in terminal bronchioles (metaplasia) and associated alveolar histiocytosis. Based on the results of these studies, we conclude that inhalation exposure of B6C3F1 mice to ozone for 24 or 30 mo (a) is carcinogenic in female B6C3F1 mice exposed to 1.0 ppm of ozone based on an increased incidence of alveolar/bronchiolar adenoma or carcinoma and (b) results in mild, site-specific, nonneoplastic lesions in the nasal cavity and centriacinar lung of male and female mice exposed to 0.5 or 1.0 ppm of ozone for 2 yrs, which persist with continued exposure to 30 mo. It is uncertain whether or not the marginal increase (p > 0.05) of alveolar/bronchiolar neoplasms in male B6C3F1 mice resulted from exposure to ozone. |
| تدمد: | 1533-1601 0192-6233 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f9211c24d475a5bbf5d7370cd15f0f https://doi.org/10.1177/019262339602400502 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f3f9211c24d475a5bbf5d7370cd15f0f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15331601 01926233 |
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