Omphalitis and Concurrent Serious Bacterial Infection
| العنوان: | Omphalitis and Concurrent Serious Bacterial Infection |
|---|---|
| المؤلفون: | Ron L, Kaplan, Andrea T, Cruz, Stephen B, Freedman, Kathleen, Smith, Julia, Freeman, Roni D, Lane, Kenneth A, Michelson, Richard D, Marble, Leah K, Middelberg, Kelly R, Bergmann, Constance, McAneney, Kathleen A, Noorbakhsh, Christopher, Pruitt, Nipam, Shah, Oluwakemi, Badaki-Makun, David, Schnadower, Amy D, Thompson, Mercedes M, Blackstone, Thomas J, Abramo, Geetanjali, Srivastava, Usha, Avva, Margaret, Samuels-Kalow, Oihane, Morientes, Nirupama, Kannikeswaran, Pradip P, Chaudhari, Jonathan, Strutt, Cheryl, Vance, Elizabeth, Haines, Kajal, Khanna, James, Gerard, Lalit, Bajaj |
| المصدر: | Pediatrics. 149 |
| بيانات النشر: | American Academy of Pediatrics (AAP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Methicillin-Resistant Staphylococcus aureus, Adolescent, Fever, Soft Tissue Infections, Infant, Newborn, Infant, Bacterial Infections, Staphylococcal Infections, Skin Diseases, Infant, Newborn, Diseases, Chorioamnionitis, Pregnancy, Pediatrics, Perinatology and Child Health, Humans, Female, Child, Retrospective Studies |
| الوصف: | OBJECTIVE Describe the clinical presentation, prevalence of concurrent serious bacterial infection (SBI), and outcomes among infants with omphalitis. METHODS Within the Pediatric Emergency Medicine Collaborative Research Committee, 28 sites reviewed records of infants ≤90 days of age with omphalitis seen in the emergency department from January 1, 2008, to December 31, 2017. Demographic, clinical, laboratory, treatment, and outcome data were summarized. RESULTS Among 566 infants (median age 16 days), 537 (95%) were well-appearing, 64 (11%) had fever at home or in the emergency department, and 143 (25%) had reported fussiness or poor feeding. Blood, urine, and cerebrospinal fluid cultures were collected in 472 (83%), 326 (58%), and 222 (39%) infants, respectively. Pathogens grew in 1.1% (95% confidence interval [CI], 0.3%–2.5%) of blood, 0.9% (95% CI, 0.2%–2.7%) of urine, and 0.9% (95% CI, 0.1%–3.2%) of cerebrospinal fluid cultures. Cultures from the site of infection were obtained in 320 (57%) infants, with 85% (95% CI, 80%–88%) growing a pathogen, most commonly methicillin-sensitive Staphylococcus aureus (62%), followed by methicillin-resistant Staphylococcus aureus (11%) and Escherichia coli (10%). Four hundred ninety-eight (88%) were hospitalized, 81 (16%) to an ICU. Twelve (2.1% [95% CI, 1.1%–3.7%]) had sepsis or shock, and 2 (0.4% [95% CI, 0.0%–1.3%]) had severe cellulitis or necrotizing soft tissue infection. There was 1 death. Serious complications occurred only in infants aged CONCLUSIONS In this multicenter cohort, mild, localized disease was typical of omphalitis. SBI and adverse outcomes were uncommon. Depending on age, routine testing for SBI is likely unnecessary in most afebrile, well-appearing infants with omphalitis. |
| تدمد: | 1098-4275 0031-4005 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4000d54e81741b34a8e74b7ced4fc23 https://doi.org/10.1542/peds.2021-054189 |
| رقم الأكسشن: | edsair.doi.dedup.....f4000d54e81741b34a8e74b7ced4fc23 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10984275 00314005 |
|---|