The effect of baicalein on endoplasmic reticulum stress and autophagy on liver damage
| العنوان: | The effect of baicalein on endoplasmic reticulum stress and autophagy on liver damage |
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| المؤلفون: | Cihan Tanrikut, Emre Entok, Derya Ustuner, Dilek Burukoglu, Umut Kerem Kolac, Mehmet Cengiz Ustuner, Z. Ozdemir Koroglu |
| المصدر: | Human & Experimental Toxicology. 40:1624-1633 |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Health, Toxicology and Mutagenesis, ATG5, Toxicology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Autophagy, Animals, Rats, Wistar, biology, Carbon Tetrachloride Poisoning, ATF6, Endoplasmic reticulum, ATF4, General Medicine, Endoplasmic Reticulum Stress, biology.organism_classification, Molecular biology, Rats, Baicalein, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Flavanones, Unfolded protein response, Scutellaria baicalensis, Female, Chemical and Drug Induced Liver Injury, Biomarkers |
| الوصف: | Carbon tetrachloride (CCl4) is a toxic chemical that causes liver injury. CCl4 triggers endoplasmic reticulum (ER) stress and unfolded protein response (UPR). UPR triggers autophagy to deal with the damage. The aim of this study was to investigate the effect of baicalein, derived from Scutellaria baicalensis, on CCl4-induced liver damage concerning ER stress and autophagy. Two groups of Wistar albino rats (n = 7/groups) were treated with 0.2 ml/kg CCl4 for 10 days with and without baicalein. Histological and transmission electron microscopy (TEM) analysis, autophagy, and ER stress markers measurements were carried out to evaluate the effect of baicalein. Histological examinations showed that baicalein reduced liver damage. TEM analysis indicated that baicalein inhibited ER stress and triggered autophagy. CCl4-induced elevation of C/EBP homologous protein (CHOP), glucose-regulating protein 78 (GRP78), activating transcription factor 4 (ATF4), activating transcription factor 6 (ATF6), inositol requiring enzyme 1 (IRE1), pancreatic ER kinase (PERK), and active/spliced form of X-box-binding protein 1 (XBP1s) ER stress markers were decreased by baicalein. Baicalein also increased the autophagy-related 5 (ATG5), Beclin1, and Microtubule-associated protein 1A/1B-light chain 3-phosphatidylethanolamine-conjugated form (LC3-II) autophagy marker levels. In conclusion, baicalein reduced the CCl4-induced liver damage by inhibiting ER stress and the trigger of autophagy. |
| تدمد: | 1477-0903 0960-3271 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f401d55eb49a32d99cda8693d54cc6d2 https://doi.org/10.1177/09603271211003634 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f401d55eb49a32d99cda8693d54cc6d2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770903 09603271 |
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