The Combined Effect of Weaning Stress and Immune Activation during Pig Gestation on Serum Cytokine and Analyte Concentrations
| العنوان: | The Combined Effect of Weaning Stress and Immune Activation during Pig Gestation on Serum Cytokine and Analyte Concentrations |
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| المؤلفون: | Courtni R Bolt, Laurie A. Rund, Bruce R. Southey, María B. Villamil, Sandra L. Rodriguez-Zas, Rodney W. Johnson, Haley E Rymut |
| المصدر: | Animals, Vol 11, Iss 2274, p 2274 (2021) Animals Volume 11 Issue 8 Animals : an Open Access Journal from MDPI |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Interleukin 2, medicine.medical_specialty, endocrine system diseases, Offspring, Veterinary medicine, interleukin 2, Article, 03 medical and health sciences, anion gap, 0302 clinical medicine, Immune system, Internal medicine, SF600-1100, medicine, Weaning, interleukin 1 beta, calcium, General Veterinary, biology, Porcine reproductive and respiratory syndrome virus, biology.organism_classification, 030104 developmental biology, Endocrinology, Blood chemistry, QL1-991, Gestation, Animal Science and Zoology, bilirubin, Zoology, 030217 neurology & neurosurgery, medicine.drug, Hormone |
| الوصف: | Simple Summary The present study of blood chemical, cytokine and hormone indicators in male and female pigs offered insights into the combined effects of maternal immune activation and weaning stress. Our results indicate that maternal immune activation may grant higher tolerance to anion gap and bilirubin disruptions triggered by weaning stress. Therefore, management practices aimed at minimizing the effects of weaning should consider the interacting effect of immune activation during development. Abstract Weaning stress can elicit changes in the metabolic, hormone and immune systems of pigs and interact with prolonged disruptions stemming from maternal immune activation (MIA) during gestation. The present study advances the characterization of the combined effects of weaning stress and MIA on blood chemistry, immune and hormone indicators that inform on the health of pigs. Three-week-old female and male offspring of control gilts or gilts infected with the porcine reproductive and respiratory syndrome virus were allocated to weaned or nursed groups. The anion gap and bilirubin profiles suggest that MIA enhances tolerance to the effects of weaning stress. Interleukin 1 beta and interleukin 2 were highest among weaned MIA females, and cortisol was higher among weaned relative to nursed pigs across sexes. Canonical discriminant analysis demonstrated that weaned and nursed pigs have distinct chemistry profiles, whereas MIA and control pigs have distinct cytokine profiles. The results from this study can guide management practices that recognize the effects of the interaction between MIA and weaning stress on the performance and health of pigs. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-2615 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40c328772e0f6ad833ce68b050dc538 https://www.mdpi.com/2076-2615/11/8/2274 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f40c328772e0f6ad833ce68b050dc538 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20762615 |
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