Surgical management of fibrotic encapsulation of the fluocinolone acetonide implant in CAPN5-associated proliferative vitreoretinopathy
| العنوان: | Surgical management of fibrotic encapsulation of the fluocinolone acetonide implant in CAPN5-associated proliferative vitreoretinopathy |
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| المؤلفون: | Vinit B. Mahajan, James C. Folk, Warren M. Sobol, Paul S. Tlucek |
| المصدر: | Clinical Ophthalmology (Auckland, N.Z.) |
| بيانات النشر: | Dove Medical Press, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, Proliferative vitreoretinopathy, Stage iv disease, medicine.medical_treatment, CAPN5, 03 medical and health sciences, 0302 clinical medicine, Fluocinolone acetonide, Fibrosis, Ophthalmology, Medicine, Case Series, 030304 developmental biology, Surgical repair, 0303 health sciences, business.industry, calpain-5, Capsule, Immunosuppression, Clinical Ophthalmology, autosomal dominant neovascular inflammatory vitreoretinopathy, fibrotic encapsulation, medicine.disease, ADNIV, 3. Good health, Retisert, 030221 ophthalmology & optometry, fluocinolone acetonide, Implant, business, medicine.drug |
| الوصف: | Paul S Tlucek,1 James C Folk,1 Warren M Sobol,2 Vinit B Mahajan1,3 1Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA; 2Retina Physicians and Surgeons, Dayton, OH, USA; 3Omics Laboratory, University of Iowa, Iowa City, IA, USA Objective: To review fibrosis of fluocinolone acetonide (FA) implants in subjects with CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV). Methods: A retrospective case series was assembled from ADNIV patients in which there was fibrotic encapsulation of a fluocinolone acetonide implant. CAPN5 genotypes and surgical repair techniques were reviewed. Results: Two eyes of two ADNIV patients developed a fibrotic capsule over the fluocinolone acetonide implant. Both patients had Stage IV disease. Patient A had a c.731T > C mutation in the CAPN5 gene and patient B had a c.728G > T mutation. The fibrotic membrane was surgically excised and the implant function was restored. Conclusion: The exuberant fibrotic response in later stages of ADNIV may be resistant to local immunosuppression with steroids. Surgical excision of fibrotic membranes over FA implants can reestablish local steroid delivery in cases of severe proliferative vitreoretinopathy. Keywords: autosomal dominant neovascular inflammatory vitreoretinopathy, ADNIV, CAPN5, calpain-5, Retisert, fluocinolone acetonide, fibrotic encapsulation |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1177-5483 1177-5467 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41a53fe75f3500b5813ae1181bd30c0 http://europepmc.org/articles/PMC3682853 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f41a53fe75f3500b5813ae1181bd30c0 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 11775483 11775467 |
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