Outcome and complications of pediatric acute promyelocytic leukemia in Bangladesh
| العنوان: | Outcome and complications of pediatric acute promyelocytic leukemia in Bangladesh |
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| المؤلفون: | Eshita Reza Khan, Afiqul Islam, Chowdhury Yakub Jamal, Md. Anwarul Karim, ATM Atikur Rahman, Md. Golam Hafiz, Abdul Khaleque |
| المصدر: | Pediatric Hematology and Oncology. 39:406-417 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Bangladesh, Leukemia, Promyelocytic, Acute, Oncology, Neoplasms, Sepsis, Pediatrics, Perinatology and Child Health, Humans, Tretinoin, Hematology, Child |
| الوصف: | Pediatric acute promyelocytic leukemia (APL) is one of the most curable subtypes of acute myeloid leukemia of childhood. But it may have many early complications, especially in developing countries. This study aims to describe the outcome and complications of pediatric APL patients in Bangladesh. This prospective observational study was conducted in the pediatric hematology and oncology department of Bangabandhu Sheikh Mujib Medical University, Dhaka from September 2017 to March 2019. In this study, PML:RAR-α (Promyelocytic leukemia-retinoic acid receptor-α) positive APL cases were included and observed while being treated with risk-directed ATRA (All-trans-retinoic acid) based chemotherapy. Among twenty PML:RAR-α positive APL cases, 13 children were in the high risk group and hemorrhagic manifestations were present in 95% of patients. Post-induction remission was achieved in 85% of the patients. 3-year overall survival was 70% (45-85% with 95% confidence interval). There was no refractory disease or relapses. Neutropenic sepsis was the most common complication and also the most common cause of mortality. In Bangladesh, the 3-year overall survival of pediatric APL is 70% (45-85% with 95% CI). Post-chemotherapy neutropenic sepsis is the most common complication and also the most common cause of mortality in this potentially curable malignancy in Bangladesh. |
| تدمد: | 1521-0669 0888-0018 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f445eb37521ee1e73d0f8bbc2116d9c2 https://doi.org/10.1080/08880018.2021.2002486 |
| رقم الأكسشن: | edsair.doi.dedup.....f445eb37521ee1e73d0f8bbc2116d9c2 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15210669 08880018 |
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