Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria
| العنوان: | Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria |
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| المؤلفون: | Frédéric Canini, Cécile Batandier, Anne-Marie Roussel, Richard A. Anderson, Karine Couturier, Laurent Poulet, Isabelle Hininger |
| المساهمون: | Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Beltsville Human Nutrition Research Center, Institut de Recherche Biomédicale des Armées (IRBA), ANR-07-PNRA-0003,CERVIRMIT,Cerveau, résistance à l'insuline et mitochondrie :Rôle neuroprotecteur des polyphénols de la cannelle dans un modèle animal de syndrome métabolique(2007) |
| المصدر: | Journal of Nutritional Biochemistry Journal of Nutritional Biochemistry, Elsevier, 2016, 28, pp.183-190. ⟨10.1016/j.jnutbio.2015.10.016⟩ |
| بيانات النشر: | HAL CCSD, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Antioxidant, Cinnamomum zeylanicum, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Clinical Biochemistry, Biology, Mitochondrion, Biochemistry, p38 Mitogen-Activated Protein Kinases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, Internal medicine, medicine, Animals, Rats, Wistar, Molecular Biology, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, Nutrition and Dietetics, Insulin, MPTP, Adenylate Kinase, Brain, Rotenone, medicine.disease, Mitochondria, Rats, Oxidative Stress, 030104 developmental biology, Endocrinology, chemistry, Mitochondrial permeability transition pore, Metabolic syndrome, Insulin Resistance, Reactive Oxygen Species, 030217 neurology & neurosurgery, Signal Transduction |
| الوصف: | Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF(2)), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca(2+) retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF(2) diet dramatically decreased the amount of Ca(2+) required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF(2) diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. |
| اللغة: | English |
| تدمد: | 0955-2863 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f497725c21e6fcddd470f0a175bfe249 https://hal.univ-grenoble-alpes.fr/hal-01930833 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f497725c21e6fcddd470f0a175bfe249 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09552863 |
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