Parenteral administration of GM1 ganglioside to presenile Alzheimer patients
| العنوان: | Parenteral administration of GM1 ganglioside to presenile Alzheimer patients |
|---|---|
| المؤلفون: | Lars Svennerholm, J.-E. Månsson, G. Toffano, Pam Fredman, Ingvar Karlsson, Anders Wallin, Kaj Blennow, C. G. Gottfries |
| المصدر: | Acta Neurologica Scandinavica. 81:48-53 |
| بيانات النشر: | Hindawi Limited, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Blood level, medicine.medical_specialty, Injections, Subcutaneous, medicine.medical_treatment, G(M1) Ganglioside, Injections, Intramuscular, Degenerative disease, Pharmacokinetics, Alzheimer Disease, Internal medicine, medicine, Humans, Aged, Chemotherapy, Ganglioside, business.industry, Mean age, General Medicine, Middle Aged, medicine.disease, Gm1 ganglioside, Endocrinology, Neurology, Neurology (clinical), Alzheimer's disease, business |
| الوصف: | The pharmacokinetic parameters of GM1 ganglioside were examined in 16 patients (mean age 64 +/- 5 years) with Alzheimer's disease. The ganglioside was given intramuscularly and subcutaneously. The maximum GM1 blood level was reached after 48-72 h, the subcutaneous route leading to the highest blood levels, but the individual variability was relatively large. When 100 mg GM1 ganglioside was given daily for a week, maximum serum values of 15 to 20 mumol/l were found in 3 patients. The elimination half-life from serum was 60-75 h. |
| تدمد: | 1600-0404 0001-6314 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e2335354aeecdae14921211bfa1482 https://doi.org/10.1111/j.1600-0404.1990.tb00930.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f4e2335354aeecdae14921211bfa1482 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000404 00016314 |
|---|