Sub-Staging-Specific Differences in Recurrence-Free, Progression-Free, and Cancer-Specific Survival for Patients with T1 Bladder Cancer: A Systematic Review and Meta-Analysis
| العنوان: | Sub-Staging-Specific Differences in Recurrence-Free, Progression-Free, and Cancer-Specific Survival for Patients with T1 Bladder Cancer: A Systematic Review and Meta-Analysis |
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| المؤلفون: | Mengzhao Zhang, Jinhai Fan, Guanqiu Chen, Tao Yang, Qiuya Shao, Pu Zhang, Bo Yang |
| المصدر: | Urologia Internationalis. 104:580-586 |
| بيانات النشر: | S. Karger AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Muscularis mucosae, Bladder cancer, business.industry, Urology, Hazard ratio, MEDLINE, Cochrane Library, medicine.disease, Cancer specific survival, Confidence interval, Survival Rate, Urinary Bladder Neoplasms, Meta-analysis, Internal medicine, Disease Progression, medicine, Humans, Neoplasm Recurrence, Local, business, Neoplasm Staging |
| الوصف: | Introduction: The efficiency of the T1 sub-staging system on categorizing bladder cancer (BC) patients into subgroups with different clinical outcomes was unclear. We summarized relevant evidences, including recurrence-free survival (RFS), progression-free survival (PFS), and cancer-specific survival (CSS), to analyze the prognostic significance of T1 sub-stage. Methods: Systematic literature searches of MEDLINE, EMBASE, and the Cochrane Library were performed. We pooled data on recurrence, progression, and CSS from 35 studies. Results: The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) indicated the difference in RFS between T1a sub-stage and T1b sub-stage (HR 1.28, 95% CI 1.14–1.43, p < 0.001). The significant difference was observed in PFS between the 2 arms (HR 2.18, 95% CI 1.95–2.44, p < 0.001). Worse CSS was found in T1b patients than in T1a patients (HR 1.36, 95% CI 1.21–1.54, p < 0.001). Conclusions: T1 sub-staging system based on the invasion depth into muscularis mucosae can be a significant prognostic factor for RFS, PFS, and CSS of patients with T1 BC. Urologists and pathologists are encouraged to work together to give a precise sub-stage classification of T1 BC, and T1 sub-staging system should be a routine part of any histopathological report when possible. Different treatment strategies need to be developed for both T1a BC and T1b BC. |
| تدمد: | 1423-0399 0042-1138 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f8f6b246a0b90308fed73ea36efa14 https://doi.org/10.1159/000506238 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f4f8f6b246a0b90308fed73ea36efa14 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230399 00421138 |
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