Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects
| العنوان: | Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects |
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| المؤلفون: | Michal Repisky, Kateřina Hönigová, Shib Shankar Paul, Tomáš Vaculovič, Karolina Wawrocka, Ben Joseph R Cuyacot, Radek Marek, Jaromír Marek, Michal Masařík, Jan Chyba, Martin Sojka, Abril C. Castro, Jan Novotný |
| المصدر: | Inorganic Chemistry. 60:17911-17925 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Macrocyclic Compounds, Organoplatinum Compounds, Cell Survival, Macromolecular Substances, Supramolecular chemistry, chemistry.chemical_element, Antineoplastic Agents, 010402 general chemistry, 01 natural sciences, Inorganic Chemistry, Hydrolysis, Tumor Cells, Cultured, medicine, Humans, Physical and Theoretical Chemistry, Cytotoxicity, Density Functional Theory, Cell Proliferation, Cisplatin, Molecular Structure, 010405 organic chemistry, Cationic polymerization, Combinatorial chemistry, 0104 chemical sciences, chemistry, Drug Screening Assays, Antitumor, Platinum, Drug carrier, Cis–trans isomerism, medicine.drug |
| الوصف: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Inorganic Chemistry", copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.inorgchem.1c02467. Platinum-based anticancer drugs are actively developed utilizing lipophilic ligands or drug carriers for the efficient penetration of biomembranes, reduction of side effects, and tumor targeting. We report the development of a supramolecular host–guest system built on cationic platinum(II) compounds bearing ligands anchored in the cavity of the macrocyclic host. The host–guest binding and hydrolysis process on the platinum core were investigated in detail by using NMR, MS, X-ray diffraction, and relativistic DFT calculations. The encapsulation process in cucurbit[7]uril unequivocally promotes the stability of hydrolyzed dicationic cis-[PtII(NH3)2(H2O)(NH2-R)]2+ compared to its trans isomer. Biological screening on the ovarian cancer lines A2780 and A2780/CP shows time-dependent toxicity. Notably, the reported complex and its β-cyclodextrin (β-CD) assembly achieve the same cellular uptake as cisplatin and cisplatin@β-CD, respectively, while maintaining a significantly lower toxicity profile. |
| تدمد: | 1520-510X 0020-1669 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f501abbc7479f8ccfb65a9f8c5e30dee https://doi.org/10.1021/acs.inorgchem.1c02467 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f501abbc7479f8ccfb65a9f8c5e30dee |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 1520510X 00201669 |
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