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Genomic analysis of the domestication and post-Spanish conquest evolution of the llama and alpaca

التفاصيل البيبلوغرافية
العنوان: Genomic analysis of the domestication and post-Spanish conquest evolution of the llama and alpaca
المؤلفون: Valeria Varas, Xukui Yang, Benito A. González, Xiaohui Sun, Shengkai Pan, Mario Barbato, Erli Li, Jane V. Wheeler, Chi Zhang, Kasper Munch, Yafei Hu, Changsheng Dong, Junping He, Russel Corbett-Detig, Ruiwen Fan, Juan C. Marín, Zhongru Gu, Michael William Bruford, Wenjun Gao, Xuanmin Guang, Xiangjiang Zhan
المصدر: Genome Biology, Vol 21, Iss 1, Pp 1-26 (2020)
Genome Biology
Fan, R, Gu, Z, Guang, X, Marín, J C, Varas, V, González, B A, Wheeler, J C, Hu, Y, Li, E, Sun, X, Yang, X, Zhang, C, Gao, W, He, J, Munch, K, Corbett-Detig, R, Barbato, M, Pan, S, Zhan, X, Bruford, M W & Dong, C 2020, ' Genomic analysis of the domestication and post-Spanish conquest evolution of the llama and alpaca ', Genome Biology, vol. 21, 159 . https://doi.org/10.1186/s13059-020-02080-6
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Male, lcsh:QH426-470, Introgression, Settore BIO/18 - GENETICA, Adaptation, Biological, Alpaca, Spanish conquest, Biology, Genetic Introgression, Genome, Domestication, Settore BIO/05 - ZOOLOGIA, Animals, Selection, Genetic, lcsh:QH301-705.5, Gene, Synteny, Settore AGR/17 - ZOOTECNICA GENERALE E MIGLIORAMENTO GENETICO, Llama, Research, South America, Biological Evolution, Phenotype, Human genetics, Phylogeography, lcsh:Genetics, lcsh:Biology (General), Evolutionary biology, Female, Adaptation, Camelids, New World
الوصف: Background Despite their regional economic importance and being increasingly reared globally, the origins and evolution of the llama and alpaca remain poorly understood. Here we report reference genomes for the llama, and for the guanaco and vicuña (their putative wild progenitors), compare these with the published alpaca genome, and resequence seven individuals of all four species to better understand domestication and introgression between the llama and alpaca. Results Phylogenomic analysis confirms that the llama was domesticated from the guanaco and the alpaca from the vicuña. Introgression was much higher in the alpaca genome (36%) than the llama (5%) and could be dated close to the time of the Spanish conquest, approximately 500 years ago. Introgression patterns are at their most variable on the X-chromosome of the alpaca, featuring 53 genes known to have deleterious X-linked phenotypes in humans. Strong genome-wide introgression signatures include olfactory receptor complexes into both species, hypertension resistance into alpaca, and fleece/fiber traits into llama. Genomic signatures of domestication in the llama include male reproductive traits, while in alpaca feature fleece characteristics, olfaction-related and hypoxia adaptation traits. Expression analysis of the introgressed region that is syntenic to human HSA4q21, a gene cluster previously associated with hypertension in humans under hypoxic conditions, shows a previously undocumented role for PRDM8 downregulation as a potential transcriptional regulation mechanism, analogous to that previously reported at high altitude for hypoxia-inducible factor 1α. Conclusions The unprecedented introgression signatures within both domestic camelid genomes may reflect post-conquest changes in agriculture and the breakdown of traditional management practices.
وصف الملف: application/pdf
تدمد: 1474-760X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5329defca44b828f4e7bc2d290f5eab
https://doi.org/10.1186/s13059-020-02080-6
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....f5329defca44b828f4e7bc2d290f5eab
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1474760X