Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging
| العنوان: | Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging |
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| المؤلفون: | Jacopo Ferruzzi, Jay D. Humphrey, Bart Spronck, Alexander W. Caulk, Sae-Il Murtada, Chiara Bellini |
| المساهمون: | Biomedische Technologie, RS: Carim - H07 Cardiovascular System Dynamics |
| المصدر: | Journal of Hypertension, 38(7), 1312-1321. LIPPINCOTT WILLIAMS & WILKINS Journal of hypertension Journal of Hypertension |
| بيانات النشر: | LIPPINCOTT WILLIAMS & WILKINS, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Aging, FIBULIN-5, Physiology, Hemodynamics, Aorta, Thoracic, 030204 cardiovascular system & hematology, MOUSE, PRESSURE-DEPENDENCE, Mice, stiffness, 0302 clinical medicine, Central Artery, Thoracic aorta, salt, Aorta, Abdominal, 030212 general & internal medicine, biology, nitric oxide synthase, Angiotensin II, WALL, Nitric oxide synthase, NG-Nitroarginine Methyl Ester, Phenotype, medicine.anatomical_structure, arterial stiffness, pulse-wave velocity, Hypertension, Female, Cardiology and Cardiovascular Medicine, Elastic fiber, medicine.medical_specialty, Nitric Oxide Synthase Type III, Article, 03 medical and health sciences, medicine.artery, Internal medicine, Internal Medicine, medicine, Animals, Sodium Chloride, Dietary, HALLMARKS, Aorta, business.industry, angiotensin, aorta, Blood pressure, Endocrinology, biology.protein, business |
| الوصف: | Objectives Increased central artery stiffness associates with cardiovascular disease. Among other factors, hypertension and aging are strong contributors to central artery stiffening, yet it has been difficult to separate their effects. Herein, we study isolated and combined effects of hypertension and aging on central artery remodeling in multiple mouse models as a function of sex. Methods We biomechanically phenotyped the aorta as a function of two different methods of inducing hypertension [infusion of angiotensin II (AngII) or combining a high salt diet with inhibition of endothelial-derived nitric oxide synthase using L-NAME] in male and female wild-type and fibulin-5 null mice, the latter of which models aspects of aortic aging. Results Despite increasing blood pressure similarly, salt + L-NAME led to adaptive and maladaptive remodeling in the abdominal and thoracic aorta, respectively, whereas AngII caused luminal dilatation but little remodeling of the wall. Importantly, effects of aging were more dramatic than those resulting from induced hypertension and, consequently, superimposing hypertension on aging led to modest additional changes in luminal radius and wall thickness, though wall stress and stiffness increased mainly because of the elevated pressure. Conclusion Our results suggest that effects of hypertension on aortic remodeling are modest when superimposed on aging in mice, largely independent of sex. These findings are consistent with general observations in humans and in spontaneously hypertensive rats, though separated here for the first time in a rodent model characterized by a severe loss of elastic fiber integrity similar to that found in the aged human aorta. |
| اللغة: | English |
| تدمد: | 1473-5598 0263-6352 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f573452436a8b2ae94427a5177b90852 https://doi.org/10.1097/HJH.0000000000002400 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f573452436a8b2ae94427a5177b90852 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14735598 02636352 |
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