Phosphonate/zwitterionic/cationic terpolymers as high-efficiency bactericidal and antifouling coatings for metallic substrates
| العنوان: | Phosphonate/zwitterionic/cationic terpolymers as high-efficiency bactericidal and antifouling coatings for metallic substrates |
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| المؤلفون: | Wan Peng, Li Liu, Pingsheng Liu, Xiaohan Dong, Xiao Zhang, Yahui Gu, Donglin Gan, Zhuangzhuang Ma |
| المصدر: | Journal of Materials Chemistry B. 9:4169-4177 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Staphylococcus aureus, Biofouling, Polymers, Organophosphonates, Biomedical Engineering, Microbial Sensitivity Tests, engineering.material, Contact angle, Metal, chemistry.chemical_compound, Coated Materials, Biocompatible, Coating, Coordination Complexes, Cations, Materials Testing, Escherichia coli, General Materials Science, chemistry.chemical_classification, Cationic polymerization, Chain transfer, General Chemistry, General Medicine, Polymer, Phosphonate, Combinatorial chemistry, Anti-Bacterial Agents, chemistry, Polymerization, visual_art, engineering, visual_art.visual_art_medium |
| الوصف: | Bacteria associated infection is a critical challenge for metallic implants and devices in biomedical applications. Here, we report phosphonate/zwitterionic/quaternary amine terpolymers as a new type of antifouling and bactericidal coating for metallic substrates. Through reversible-addition fragmentation chain transfer polymerization (RAFT) and quaternization, well-controlled phosphonate/zwitterionic/cationic terpolymers with identical phosphonate segments (repeat units of 15) and varied zwitterionic and cationic components (nSBMA : nTMAEMA = 64 : 0, 54 : 18, 18 : 32, 9 : 52, and 0 : 70) were precisely prepared. The polymers can be coated on TC4 substrates based on the strong coordination between phosphonate groups and metallic substrates, as evidenced by water contact angle and XPS tests. Bactericidal evaluation revealed that the antibacterial efficiency was enhanced with the increase of cationic content in the coating polymers. TC4 substrates coated with the polymer coating with a cationic segment of 70 repeat units were able to kill 97.5 and 94.0% of S. aureus and E. coli, respectively. By virtue of the antifouling ability of the zwitterionic component and the bactericidal ability of the cationic component, the antibacterial efficiency was increased to 99.5% without significant compromising of the cytocompatibility. Meanwhile, the dual functional terpolymers could be easily applied on other metallic substrates, such as titanium, stainless steel, and Ni/Cr alloy, which were able to kill up to 97.9% of S. aureus and 99.9% of E. coli, respectively, endowing the excellent antibacterial properties to general bio-metals. The high-efficiency antibacterial modification strategy demonstrated here may find many applications on metallic implants and devices to combat bacterial associated infections. |
| تدمد: | 2050-7518 2050-750X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5961f9e465c3103c535aea719e14a1b https://doi.org/10.1039/d1tb00770j |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f5961f9e465c3103c535aea719e14a1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20507518 2050750X |
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