Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection
| العنوان: | Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection |
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| المؤلفون: | Jean-François Eléouët, Ralph A. Schmid, Quentin Haas, Artur Summerfield, Kemal Mehinagic, Beatrice Zumkehr, Sean R R Hall, Nicolas Ruggli, B. Oliveira Esteves, Melanie Brügger, Marie-Anne Rameix-Welti, Thomas Démoulins, Thomas M. Marti, Ueli Moehrlen, Horst Posthaus, A. Schogler, G. T. Barut, Marco P. Alves |
| المساهمون: | Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Bern, Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University Children’s Hospital Zurich, Bern University Hospital [Berne] (Inselspital), Gillies McIndoe Research Institute (GMRI), Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, SNF: 310030_172895 Gottfried und Julia Bangerter-Rhyner-Stiftung, This work acknowledges support from the Swiss National Science Foundation to MPA (www.snf.ch, project 310030_172895), that included partial salary support for MB and TD. This work was also supported by a grant from the Gottfried and Julia Bangerter-Rhyner Foundation to MPA (www.bangerter-stiftung.ch), that included partial salary support to MB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., HAL UVSQ, Équipe, University of Zurich, Alves, Marco P |
| المصدر: | PLoS Pathogens PLoS Pathogens, Public Library of Science, 2021, 17 (7), pp.e1009789. ⟨10.1371/journal.ppat.1009789⟩ PLoS Pathogens, Public Library of Science, 2021, 17 (7), pp.1-28. ⟨10.1371/journal.ppat.1009789⟩ PLoS Pathogens, 2021, 17 (7), pp.1-28. ⟨10.1371/journal.ppat.1009789⟩ PLoS Pathogens, Vol 17, Iss 7, p e1009789 (2021) Brügger, Melanie; Démoulins, Thomas; Barut, G. Tuba; Zumkehr, Beatrice; Oliveira Esteves, Blandina I.; Mehinagic, Kemal; Haas, Quentin; Schögler, Aline; Rameix-Welti, Marie-Anne; Eléouët, Jean-François; Moehrlen, Ueli; Marti, Thomas M.; Schmid, Ralph A.; Summerfield, Artur; Posthaus, Horst; Ruggli, Nicolas; Hall, Sean R. R.; Alves, Marco P. (2021). Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection. PLoS pathogens, 17(7), e1009789. Public Library of Science 10.1371/journal.ppat.1009789 <http://dx.doi.org/10.1371/journal.ppat.1009789> |
| بيانات النشر: | Public Library of Science, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pulmonology, Angiogenesis, Physiology, [SDV]Life Sciences [q-bio], 2405 Parasitology, Pediatrics, 0302 clinical medicine, Medical Conditions, Animal Cells, Immune Physiology, Medicine and Health Sciences, Respiratory system, Biology (General), Lung, 0303 health sciences, Innate Immune System, 630 Agriculture, Stem Cells, 2404 Microbiology, Cell Differentiation, respiratory system, 3. Good health, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Infectious Diseases, 030220 oncology & carcinogenesis, Cytokines, Cellular Types, Pediatric Infections, Research Article, Stromal cell, QH301-705.5, T cell, Immunology, Acute Lung Injury, 610 Medicine & health, Respiratory Syncytial Virus Infections, Lung injury, Biology, Virus, 03 medical and health sciences, Respiratory Disorders, 1311 Genetics, medicine, 1312 Molecular Biology, Animals, Humans, 10220 Clinic for Surgery, Respiratory Physiology, 030304 developmental biology, 2403 Immunology, Sheep, Regeneration (biology), Mesenchymal stem cell, Biology and Life Sciences, Mesenchymal Stem Cells, Convalescence, Cell Biology, RC581-607, Molecular Development, Health Care, Immune System, Respiratory Syncytial Virus, Human, Respiratory Infections, 2406 Virology, Immunologic diseases. Allergy, Developmental Biology |
| الوصف: | Lung-resident (LR) mesenchymal stem and stromal cells (MSCs) are key elements of the alveolar niche and fundamental regulators of homeostasis and regeneration. We interrogated their function during virus-induced lung injury using the highly prevalent respiratory syncytial virus (RSV) which causes severe outcomes in infants. We applied complementary approaches with primary pediatric LR-MSCs and a state-of-the-art model of human RSV infection in lamb. Remarkably, RSV-infection of pediatric LR-MSCs led to a robust activation, characterized by a strong antiviral and pro-inflammatory phenotype combined with mediators related to T cell function. In line with this, following in vivo infection, RSV invades and activates LR-MSCs, resulting in the expansion of the pulmonary MSC pool. Moreover, the global transcriptional response of LR-MSCs appears to follow RSV disease, switching from an early antiviral signature to repair mechanisms including differentiation, tissue remodeling, and angiogenesis. These findings demonstrate the involvement of LR-MSCs during virus-mediated acute lung injury and may have therapeutic implications. Author summary This work identifies a novel function of lung-resident MSCs during virus-induced acute lung injury. These findings contribute to the understanding of host response and lung repair mechanisms during a highly prevalent clinical situation and may have therapeutic implications. |
| وصف الملف: | application/pdf; journal.ppat.1009789.pdf - application/pdf |
| اللغة: | English |
| تدمد: | 1553-7374 1553-7366 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c141c2012e2ea49a9660f9a7503c74 http://europepmc.org/articles/PMC8351988 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f5c141c2012e2ea49a9660f9a7503c74 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15537374 15537366 |
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