Phage‐assisted , active site‐directed ligand evolution of a potent and selective histone deacetylase 8 inhibitor
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| المؤلفون: | Jared S. Morse, Yan J. Sheng, Joshua Trae Hampton, Lauralee D. Sylvain, Sukant Das, Yugendar R. Alugubelli, Peng‐Hsun Chase Chen, Kai S. Yang, Shiqing Xu, Carol A. Fierke, Wenshe Ray Liu |
| المصدر: | Protein Science. 31 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Histone Deacetylase Inhibitors, Catalytic Domain, Codon, Terminator, Escherichia coli, Bacteriophages, Amino Acids, Ketones, Ligands, Peptides, Molecular Biology, Biochemistry, Histone Deacetylases |
| الوصف: | Phage-assisted, active site-directed ligand evolution (PADLE) is a recently developed technique that uses an amber codon-encoded noncanonical amino acid (ncAA) as an anchor to direct phage-displayed peptides to a target for an enhanced ligand identification process. 2-Amino-8-oxodecanoic acid (Aoda) is a ketone-containing ncAA residue in the macrocyclic peptide natural product apicidin that is a pan-inhibitor of Zn |
| تدمد: | 1469-896X 0961-8368 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cefb4d378f01bb20140799625eaa37 https://doi.org/10.1002/pro.4512 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f5cefb4d378f01bb20140799625eaa37 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1469896X 09618368 |
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