Common Developmental Pathway for Primitive Erythrocytes and Multipotent Hematopoietic Progenitors in Early Mouse Development
| العنوان: | Common Developmental Pathway for Primitive Erythrocytes and Multipotent Hematopoietic Progenitors in Early Mouse Development |
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| المؤلفون: | Hidetoshi Yamazaki, Toshiyuki Yamane, Aya Washino |
| المصدر: | Stem Cell Reports |
| بيانات النشر: | Elsevier, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Erythrocytes, Cell, Population, Embryonic Development, Cell Separation, Biology, Biochemistry, Article, Mice, Genetics, medicine, Animals, Cell Lineage, Progenitor cell, education, education.field_of_study, Multipotent Stem Cells, Gene Expression Regulation, Developmental, Embryo, Cell Differentiation, Cell Biology, Hematopoietic Stem Cells, Embryonic stem cell, Cell biology, Mice, Inbred C57BL, Haematopoiesis, medicine.anatomical_structure, Immunology, Hemangioblast, Stem cell, Developmental Biology |
| الوصف: | Summary Development of the hematopoietic system proceeds in a multistep manner. Primitive erythrocytes are the first hematopoietic cells to be observed that were produced transiently in developing embryos. Multilineage lymphohematopoiesis occurs after the primitive erythropoiesis. However, the lineage relationship of cells that comprise embryonic hematopoietic system is not well characterized. To clarify this process, careful analyses of the embryonic cells that differentiate into these cell lineages are necessary. We identified the common precursors of primitive erythrocytes and multipotent hematopoietic cells in mouse embryonic stem cell cultures and mouse embryos. A subset defined as CD45−CD41+AA4.1− cells showed bipotential capability to produce primitive erythrocytes and lymphomyeloid cells at the single-cell level. The cell population was present in vivo before hematopoietic stem cells (HSCs) appeared. Our results show that primitive erythrocytes and lymphomyeloid cells are not completely separate cell lineages, and these precursors comprise the embryonic hematopoietic system before HSC emergence. Highlights • Primitive erythrocytes and lymphomyeloid progenitors have bipotent precursors • The precursors form primitive erythroid and lymphomyeloid cells in distinct waves • The common precursors are noted in the yolk sac and embryo proper • Primitive erythrocytes and lymphocytes can be derived from a single precursor cell Yamane and colleagues show that there is a bipotential cell stage for the primitive erythrocytes that are produced transiently in embryos and multipotent hematopoietic progenitors that supply lymphoid and myeloid cells during the early stage of mouse development. Primitive erythrocytes and lymphomyeloid cells are not completely separate cell lineages. |
| اللغة: | English |
| تدمد: | 2213-6711 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f606e62e8091550708cce1619ebd4037 http://europepmc.org/articles/PMC3871389 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f606e62e8091550708cce1619ebd4037 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22136711 |
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