NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
| العنوان: | NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model |
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| المؤلفون: | Huating Wang, Jin Mo Gu, Jennifer M. Peterson, Sandya Liyanarachchi, Christopher E. Gaw, Vikram Shettigar, Mark T. Ziolo, Benjamin D. Canan, Jennifer M. Petrosino, Steve R. Roof, Sudarshana M. Sharma, Denis C. Guttridge, Nadine Bakkar, David J. Wang, Leina Lu, Paul M.L. Janssen, Jonathan P. Davis, Sean C. Little, Priya Londhe, Jonathan Shintaku, Nivedita M. Ratnam |
| المصدر: | Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018) Nature Communications |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, musculoskeletal diseases, 0301 basic medicine, CCCTC-Binding Factor, Science, Duchenne muscular dystrophy, Cardiomyopathy, General Physics and Astronomy, Histone Deacetylase 1, Article, Sodium-Calcium Exchanger, General Biochemistry, Genetics and Molecular Biology, Muscle hypertrophy, Mice, 03 medical and health sciences, 0302 clinical medicine, Animals, Medicine, Myocyte, Myocytes, Cardiac, Muscular dystrophy, lcsh:Science, Cells, Cultured, Multidisciplinary, business.industry, NF-kappa B, Skeletal muscle, General Chemistry, Chromatin Assembly and Disassembly, medicine.disease, HDAC1, Cell biology, Chromatin, Muscular Dystrophy, Duchenne, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex, 030104 developmental biology, medicine.anatomical_structure, Mice, Inbred mdx, Calcium, lcsh:Q, business, 030217 neurology & neurosurgery, Signal Transduction |
| الوصف: | Duchenne muscular dystrophy (DMD) is a neuromuscular disorder causing progressive muscle degeneration. Although cardiomyopathy is a leading mortality cause in DMD patients, the mechanisms underlying heart failure are not well understood. Previously, we showed that NF-κB exacerbates DMD skeletal muscle pathology by promoting inflammation and impairing new muscle growth. Here, we show that NF-κB is activated in murine dystrophic (mdx) hearts, and that cardiomyocyte ablation of NF-κB rescues cardiac function. This physiological improvement is associated with a signature of upregulated calcium genes, coinciding with global enrichment of permissive H3K27 acetylation chromatin marks and depletion of the transcriptional repressors CCCTC-binding factor, SIN3 transcription regulator family member A, and histone deacetylase 1. In this respect, in DMD hearts, NF-κB acts differently from its established role as a transcriptional activator, instead promoting global changes in the chromatin landscape to regulate calcium genes and cardiac function. The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expression. |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63bf87ccb4cd7d383c6c439c75e5c0f https://doi.org/10.1038/s41467-018-05910-1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f63bf87ccb4cd7d383c6c439c75e5c0f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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