Social isolation and the brain: effects and mechanisms
| العنوان: | Social isolation and the brain: effects and mechanisms |
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| المؤلفون: | Ying Xiong, CIRONG LIU, Huilin Hong, Yong Q. Zhang |
| المصدر: | Molecular Psychiatry. 28:191-201 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cellular and Molecular Neuroscience, Psychiatry and Mental health, Molecular Biology |
| الوصف: | An obvious consequence of the coronavirus disease (COVID-19) pandemic is the worldwide reduction in social interaction, which is associated with many adverse effects on health in humans from babies to adults. Although social development under normal or isolated environments has been studied since the 1940s, the mechanism underlying social isolation (SI)-induced brain dysfunction remains poorly understood, possibly due to the complexity of SI in humans and translational gaps in findings from animal models. Herein, we present a systematic review that focused on brain changes at the molecular, cellular, structural and functional levels induced by SI at different ages and in different animal models. SI studies in humans and animal models revealed common socioemotional and cognitive deficits caused by SI in early life and an increased occurrence of depression and anxiety induced by SI during later stages of life. Altered neurotransmission and neural circuitry as well as abnormal development and function of glial cells in specific brain regions may contribute to the abnormal emotions and behaviors induced by SI. We highlight distinct alterations in oligodendrocyte progenitor cell differentiation and oligodendrocyte maturation caused by SI in early life and later stages of life, respectively, which may affect neural circuit formation and function and result in diverse brain dysfunctions. To further bridge animal and human SI studies, we propose alternative animal models with brain structures and complex social behaviors similar to those of humans. |
| تدمد: | 1476-5578 1359-4184 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66f85a46dc1b8e4c525490abf37d471 https://doi.org/10.1038/s41380-022-01835-w |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f66f85a46dc1b8e4c525490abf37d471 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14765578 13594184 |
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