Vascular syndromes in liver cirrhosis
| العنوان: | Vascular syndromes in liver cirrhosis |
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| المؤلفون: | Botros B. Shenoda, Joseph M. Boselli |
| المصدر: | Clinical Journal of Gastroenterology. 12:387-397 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Liver Cirrhosis, Pulmonary Circulation, Hepatorenal Syndrome, Cirrhosis, Hypertension, Pulmonary, medicine.medical_treatment, Collateral Circulation, Liver transplantation, Bioinformatics, Chronic liver disease, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Hepatorenal syndrome, Hypertension, Portal, medicine, Humans, Splanchnic Circulation, Vascular Diseases, Hepatopulmonary syndrome, Portopulmonary hypertension, business.industry, Gastroenterology, Syndrome, General Medicine, medicine.disease, Vasodilation, 030220 oncology & carcinogenesis, Hyperdynamic circulation, 030211 gastroenterology & hepatology, business, Hepatopulmonary Syndrome, Liver Circulation |
| الوصف: | Liver cirrhosis is associated with multiple vascular syndromes affecting almost all body systems. Many of these syndromes are directly related to impaired liver function and sometimes reversible after liver transplantation while others arise secondary to portal hypertension and ascites. Altered expression of angiogenic and vasoactive compounds (most importantly nitric oxide), endothelial dysfunction, dysregulated neurohormonal control, and systemic inflammatory state play differential roles in mediating homeostatic instability and abnormal vasogenic response. Important vascular features encountered in liver disease include portal hypertension, splanchnic overflow, abnormal angiogenesis and shunts, portopulmonary syndrome, hepatopulmonary syndrome, and systemic hyperdynamic circulation. Redistribution of effective circulatory volume deviating from vital organs and pooling in splanchnic circulation is also encountered in liver patients which may lead to devastating outcomes as hepatorenal syndrome. Etiologically, vascular syndromes are not isolated phenomena and vascular dysfunction in one system may lead to the development of another in a different system. This review focuses on understanding the pathophysiological factors underlying vascular syndromes related to chronic liver disease and the potential links among them. Many of these syndromes are associated with high mortality, thus it is crucial to look for early biomarkers for these syndromes and develop novel preventive and therapeutic strategies. |
| تدمد: | 1865-7265 1865-7257 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f670048f1dcfa03cf81065f0bef34636 https://doi.org/10.1007/s12328-019-00956-0 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f670048f1dcfa03cf81065f0bef34636 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18657265 18657257 |
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