Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet
| العنوان: | Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet |
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| المؤلفون: | Changhu Xue, Jingfeng Wang, Jin-Zhang Li, Jie Xu, Zhaojie Li, Xiao Tang, Yu-Ming Wang, Teruyoshi Yanagita, Yong Xue |
| المصدر: | Lipids in Health and Disease Lipids in Health and Disease, Vol 11, Iss 1, p 70 (2012) |
| بيانات النشر: | BioMed Central, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, genetic structures, Docosahexaenoic Acids, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Phospholipid, Omega-3 fatty acid, Diet, High-Fat, chemistry.chemical_compound, Mice, Endocrinology, Internal medicine, Fatty Acids, Omega-3, medicine, Animals, Omega 3 fatty acid, lcsh:RC620-627, Diet, Fat-Restricted, Triglycerides, Phospholipids, Biochemistry, medical, chemistry.chemical_classification, Mice, Inbred BALB C, Triglyceride, Cholesterol, Research, Biochemistry (medical), Fatty acid, food and beverages, Ethyl ester, Lipid metabolism, EPA, Lipid Metabolism, Eicosapentaenoic acid, DHA, lcsh:Nutritional diseases. Deficiency diseases, Biochemistry, chemistry, Eicosapentaenoic Acid, Docosahexaenoic acid, lipids (amino acids, peptides, and proteins) |
| الوصف: | Background Bioactivities of Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA) depend on their chemical forms. The present study was to investigate short term effects of triglyceride (TG), ethyl ester (EE), free fatty acid (FFA) and phospholipid (PL) forms of omega-3 fatty acid (FA) on lipid metabolism in mice, fed high fat or low fat diet. Method Male Balb/c mice were fed with 0.7% different Omega-3 fatty acid formulation: DHA bound free fatty acid (DHA-FFA), DHA bound triglyceride (DHA-TG), DHA bound ethyl ester (DHA-EE) and DHA bound phospholipid (DHA-PL) for 1 week, with dietary fat levels at 5% and 22.5%. Serum and hepatic lipid concentrations were analyzed, as well as the fatty acid composition of liver and brain. Result At low fat level, serum total cholesterol (TC) level in mice fed diets with DHA-FFA, DHA-EE and DHA-PL were significantly lower than that in the control group (P P < 0.05), DHA-EE (P < 0.05) and DHA-PL (P P P P P P Conclusion The present study suggested that not only total dietary fat content but also the molecular forms of omega-3 fatty acids contributed to lipid metabolism in mice. DHA-PL showed effective bioactivity in decreasing hepatic and serum TC, TG levels and increasing omega-3 concentration in liver and brain. |
| اللغة: | English |
| تدمد: | 1476-511X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a57410ef34f532cdf4a8792cfb39a5 http://europepmc.org/articles/PMC3393618 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f6a57410ef34f532cdf4a8792cfb39a5 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1476511X |
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