Therapeutic Effects of an Oral Chelator Targeting Skeletal Tissue Damage in Experimental Postmenopausal Osteoporosis in Rats
| العنوان: | Therapeutic Effects of an Oral Chelator Targeting Skeletal Tissue Damage in Experimental Postmenopausal Osteoporosis in Rats |
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| المؤلفون: | Gerry H. Kenner, Scott C. Miller, Ping Men, Gang Liu |
| المصدر: | Hemoglobin. 32:181-190 |
| بيانات النشر: | Informa UK Limited, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.medical_specialty, Free Radicals, medicine.drug_class, Iron, Clinical Biochemistry, Osteoporosis, Acetates, Iron Chelating Agents, medicine.disease_cause, Trientine, Skeletal tissue, Rats, Sprague-Dawley, Internal medicine, medicine, Animals, Humans, Chelation, Chelation therapy, Muscle, Skeletal, Osteoporosis, Postmenopausal, Genetics (clinical), business.industry, Biochemistry (medical), Therapeutic effect, Electron Spin Resonance Spectroscopy, Hematology, medicine.disease, Rats, Oxidative Stress, Endocrinology, Estrogen, Ovariectomized rat, Female, business, Oxidative stress |
| الوصف: | Earlier studies revealed that age-associated iron accumulation plays an important causal role in osteopenic development after estrogen deficiency. It is believed that an increase in iron content is associated with an increased likelihood of oxidative damage at the point of iron accumulation. However, there is no direct evidence that the iron accumulated in skeletal tissue causes free radical oxidative damage and consequent bone loss. Iron depletion from skeletal tissues of ovariectomized (OVX) rats was carried out with the oral chelator [1-N-docosyl-triethylenetetraminepentaacetic acid (DoTTPA)]. Results suggest the causal role of iron in oxidative damage that may lead to bone loss in the rats. The results also show the therapeutic potential of the bone-targeted chelator to protect against bone loss associated with age-iron accumulation as well as iron overload diseases. |
| تدمد: | 1532-432X 0363-0269 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70c5114ed6f1d23b1810d5251a2075c https://doi.org/10.1080/03630260701726707 |
| رقم الأكسشن: | edsair.doi.dedup.....f70c5114ed6f1d23b1810d5251a2075c |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 1532432X 03630269 |
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