HTLV-1 Tax-Specific CTL Epitope–Pulsed Dendritic Cell Therapy Reduces Proviral Load in Infected Rats with Immune Tolerance against Tax
| العنوان: | HTLV-1 Tax-Specific CTL Epitope–Pulsed Dendritic Cell Therapy Reduces Proviral Load in Infected Rats with Immune Tolerance against Tax |
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| المؤلفون: | Mari Kannagi, Yuji Murakami, Takao Masuda, Satomi Ando, Atsuhiko Hasegawa, Yasuhiro Maeda, Na Zeng, Youko Suehiro, Natsuko Takatsuka |
| المصدر: | The Journal of Immunology. 198:1210-1219 |
| بيانات النشر: | The American Association of Immunologists, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_treatment, T cell, Immunology, T-cell leukemia, CD8-Positive T-Lymphocytes, Biology, Cell Line, Immune tolerance, Interferon-gamma, 03 medical and health sciences, Proviruses, hemic and lymphatic diseases, Immune Tolerance, medicine, Animals, Humans, Immunology and Allergy, Vaccination, Dendritic Cells, Gene Products, tax, Immunotherapy, Dendritic cell, Viral Load, HTLV-I Infections, Virology, Rats, Inbred F344, Rats, CTL, 030104 developmental biology, medicine.anatomical_structure, Female, Viral load, CD8 |
| الوصف: | Adult T cell leukemia/lymphoma (ATL), a CD4+ T cell malignancy with a poor prognosis, is caused by human T cell leukemia virus type 1 (HTLV-1) infection. High proviral load (PVL) is a risk factor for the progression to ATL. We previously reported that some asymptomatic carriers had severely reduced functions of CTLs against HTLV-1 Tax, the major target Ag. Furthermore, the CTL responses tended to be inversely correlated with PVL, suggesting that weak HTLV-1–specific CTL responses may be involved in the elevation of PVL. Our previous animal studies indicated that oral HTLV-1 infection, the major route of infection, caused persistent infection with higher PVL in rats compared with other routes. In this study, we found that Tax-specific CD8+ T cells were present, but not functional, in orally infected rats as observed in some human asymptomatic carriers. Even in the infected rats with immune unresponsiveness against Tax, Tax-specific CTL epitope–pulsed dendritic cell (DC) therapy reduced the PVL and induced Tax-specific CD8+ T cells capable of proliferating and producing IFN-γ. Furthermore, we found that monocyte-derived DCs from most infected individuals still had the capacity to stimulate CMV-specific autologous CTLs in vitro, indicating that DC therapy may be applicable to most infected individuals. These data suggest that peptide-pulsed DC immunotherapy will be useful to induce functional HTLV-1–specific CTLs and decrease PVL in infected individuals with high PVL and impaired HTLV-1–specific CTL responses, thereby reducing the risk of the development of ATL. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77c23faa8021d4c7ca12fe3b561dda2 https://doi.org/10.4049/jimmunol.1601557 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f77c23faa8021d4c7ca12fe3b561dda2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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