Clinical Significance of Serglycin Expression in Human Breast Cancer Patients
| العنوان: | Clinical Significance of Serglycin Expression in Human Breast Cancer Patients |
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| المؤلفون: | Keiko, Hosoya, Kanae, Nosaka, Tomohiko, Sakabe, Makoto, Wakahara, Yuki, Oshima, Yoshimasa, Suzuki, Hiroshige, Nakamura, Yoshihisa, Umekita |
| المصدر: | Anticancer Research. 42:279-285 |
| بيانات النشر: | Anticancer Research USA Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Cancer Research, Vesicular Transport Proteins, Breast Neoplasms, General Medicine, Middle Aged, Prognosis, Disease-Free Survival, Gene Expression Regulation, Neoplastic, Oncology, Lymphatic Metastasis, Biomarkers, Tumor, Humans, Female, Proteoglycans, Mastectomy, Aged |
| الوصف: | Serglycin plays a crucial role in the aggressiveness of several types of malignancies, including breast cancer. In this study, we aimed to investigate the prognostic impact of serglycin expression in breast cancer patients, which has not been previously reported.Immunohistochemical analyses were performed on 348 resected specimens of invasive carcinomas, using antibodies against serglycin.Low serglycin expression was observed in 23% of specimens (80/348) and significantly correlated with high histological grade (p=0.001) and negative ER (p=0.013). The log-rank test showed that low serglycin expression correlated with shorter distant metastasis-free survival (DMFS) (p=0.016) and disease-specific survival (DSS) (p=0.037) in node-positive breast cancer patients. Cox's multivariate analysis revealed that low serglycin expression was an independent factor for shorter DMFS (p=0.017) and DSS (p=0.020) in node-positive breast cancer patients.Low serglycin expression is an independent predictor of unfavorable prognosis in node-positive breast cancer patients. |
| تدمد: | 1791-7530 0250-7005 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a6755a9de35bc4f065c8acb9be9a97 https://doi.org/10.21873/anticanres.15483 |
| رقم الأكسشن: | edsair.doi.dedup.....f7a6755a9de35bc4f065c8acb9be9a97 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17917530 02507005 |
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