Potential role of intestinal microflora in disease progression among patients with different stages of Hepatitis B
| العنوان: | Potential role of intestinal microflora in disease progression among patients with different stages of Hepatitis B |
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| المؤلفون: | Sixi Yang, Xuemin Zhao, Haochen Li, Ran Wang, Suting Li, Yange Chang, Fang Yang, Xinyu Cui, Xiu An Yang, Fengchun Lv, Zhishuo Mo, Yiming Zhao |
| المصدر: | Gut Pathogens Gut Pathogens, Vol 12, Iss 1, Pp 1-15 (2020) |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Cirrhosis, Gut microbiota, Disease, Biology, Gut flora, Microbiology, Group A, Group B, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Medical microbiology, Virology, medicine, lcsh:RC799-869, 16S rRNA gene sequencing, Disease progression, Research, Gastroenterology, Hepatitis B, medicine.disease, biology.organism_classification, Acute-on-chronic liver failure, 030104 developmental biology, Infectious Diseases, Immunology, lcsh:Diseases of the digestive system. Gastroenterology, 030211 gastroenterology & hepatology, Parasitology |
| الوصف: | Background Increasing evidence demonstrate that the gut microbiota is involved in the pathogenesis of liver diseases, and faecal microbiota transplantation is considered to be a promising new treatment option. However, there are no reports on the intestinal flora of asymptomatic HBV carriers using next-generation sequencing. This study intends to investigate the potential role of the intestinal microflora in predicting the progression of Hepatitis B patients in different non-cancerous stages. Results A total of 266 patients with different stages of Hepatitis B and 31 healthy controls were included in this study. Some of the subjects (217 cases) underwent 16S rRNA gene sequencing. Compared with the control group (CK), the α diversity of patients in Group A (HBV carrier) slightly increased, while that of patients in the other three groups decreased. Each group of patients, especially those in Group C (cirrhosis) and Group D (acute-on-chronic liver failure), could be separated from the CK using weighted UniFrac PCoA and ANOSIM. LEfSe revealed that 40 taxa belonging to three phyla had an LDA larger than 4. In addition to the comparison between Group B (chronic Hepatitis B) and Group C, the specific flora and potential taxonomic function were also identified. Different microbial communities were found to be highly correlated with clinical indicators and the Child-Pugh scores. Changes in the microbial community were highly related to the alternations of host metabolism, which in turn, was related to the development of Hepatitis B. Our analysis identified a total of 47 strains with potential biomarker functions at all levels except for the phylum level. Conclusions Faecal microbiota transplantation of some potential beneficial bacteria can change with the occurrence of disease, and HBV carriers might be the most suitable donors. |
| تدمد: | 1757-4749 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e65bef3c66d754e8eec04605b88526 https://doi.org/10.1186/s13099-020-00391-4 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f7e65bef3c66d754e8eec04605b88526 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17574749 |
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