Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response
| العنوان: | Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response |
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| المؤلفون: | Rida Raja, Andrea Ruiz-Velasco, Wei Liu, Namrita Kaur, Yingshu Guan |
| المصدر: | Frontiers in Physiology, Vol 12 (2021) Frontiers in Physiology |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Physiology, Mini Review, heart failure, Inflammation, 030204 cardiovascular system & hematology, Systemic inflammation, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Physiology (medical), Diabetic cardiomyopathy, Internal medicine, Diabetes mellitus, diabetic cardiomyopathy, medicine, Hyperinsulinemia, QP1-981, cardiovascular diseases, treatment, business.industry, medicine.disease, 030104 developmental biology, inflammation, Heart failure, diabetes mellitus, Cardiology, medicine.symptom, business |
| الوصف: | The incidence of heart failure (HF) continues to increase rapidly in patients with diabetes. It is marked by myocardial remodeling, including fibrosis, hypertrophy, and cell death, leading to diastolic dysfunction with or without systolic dysfunction. Diabetic cardiomyopathy (DCM) is a distinct myocardial disease in the absence of coronary artery disease. DCM is partially induced by chronic systemic inflammation, underpinned by a hostile environment due to hyperglycemia, hyperlipidemia, hyperinsulinemia, and insulin resistance. The detrimental role of leukocytes, cytokines, and chemokines is evident in the diabetic heart, yet the precise role of inflammation as a cause or consequence of DCM remains incompletely understood. Here, we provide a concise review of the inflammatory signaling mechanisms contributing to the clinical complications of diabetes-associated HF. Overall, the impact of inflammation on the onset and development of DCM suggests the potential benefits of targeting inflammatory cascades to prevent DCM. This review is tailored to outline the known effects of the current anti-diabetic drugs, anti-inflammatory therapies, and natural compounds on inflammation, which mitigate HF progression in diabetic populations. |
| تدمد: | 1664-042X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8096391dadf6b31f60553e5f83ab304 https://doi.org/10.3389/fphys.2021.694864 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f8096391dadf6b31f60553e5f83ab304 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1664042X |
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