Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians
| العنوان: | Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians |
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| المؤلفون: | Thi H. O. Nguyen, Jane Davies, Aeron C. Hurt, Carolien E van de Sandt, Malet Aban, Damian A. Oyong, Marios Koutsakos, Kim L. Harland, Steven Y. C. Tong, Jessica R. Webb, Katie L. Flanagan, Cath Blacker, Adam K. Wheatley, Peter C. Doherty, Jane Nelson, Louise C. Rowntree, Amy W. Chung, Timon Damelang, Anngie Everitt, Katherine Kedzierska, Maria Auladell, E. Bridie Clemens, Stephen J. Kent, Luca Hensen, Magdalena Plebanski, Bruce D. Wines, Jessica R. Loughland, P. Mark Hogarth, Adrian Miller |
| المساهمون: | Landsteiner Laboratory |
| المصدر: | Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, 118(41). National Academy of Sciences |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | follicular T helper cells, T-Lymphocytes, Disease, Antibodies, Viral, Lymphocyte Activation, Viral/blood, Antibodies, Viral/blood, 0302 clinical medicine, Immunology and Inflammation, Influenza, Human/immunology, Medicine, 030212 general & internal medicine, 0303 health sciences, B-Lymphocytes, Multidisciplinary, biology, Indigenous people, Antibody titer, Human/immunology, B-Lymphocytes/immunology, Biological Sciences, Influenza Vaccines/immunology, 3. Good health, Vaccination, Influenza Vaccines, Immunologic Memory/immunology, Antibody, Risk, T Follicular Helper Cells, Lymphocyte Activation/immunology, Mass Vaccination, Indigenous, Virus, Antibodies, 03 medical and health sciences, Immune system, Influenza, Human, Humans, Lymphocyte Count, Indigenous Peoples, 030304 developmental biology, B cells, business.industry, Australia, T-Lymphocytes/immunology, T Follicular Helper Cells/immunology, Influenza, Immunization, Immunoglobulin G/blood, Immunoglobulin G, Immunology, biology.protein, business, Immunologic Memory, Indigenous Peoples/statistics & numerical data |
| الوصف: | Significance Indigenous populations worldwide are highly susceptible to influenza virus infections. Vaccination with inactivated virus is highly recommended to protect Indigenous populations, including Indigenous Australians. There is no study to date that assessed immune responses induced by the inactivated seasonal influenza vaccine in the Indigenous population. Vaccine recommendations are thus based on data generated for non-Indigenous populations and might not be representative for Indigenous people. We found robust antibody responses to influenza vaccination induced in Indigenous Australians, with activation profiles of cTFH1 cells at the acute response strongly correlating with total change of antibody vaccine titers induced by vaccination. Our work strongly supports the recommendation of influenza vaccination to protect Indigenous populations from severe seasonal influenza virus infections and subsequent complications. Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigenous people globally. Although vaccination against influenza is recommended for those most at risk, studies on immune responses elicited by seasonal vaccines in Indigenous populations are largely missing, with no data available for Indigenous Australians and only one report published on antibody responses in Indigenous Canadians. We recruited 78 Indigenous and 84 non-Indigenous Australians vaccinated with the quadrivalent influenza vaccine into the Looking into InFluenza T cell immunity - Vaccination cohort study and collected blood to define baseline, early (day 7), and memory (day 28) immune responses. We performed in-depth analyses of T and B cell activation, formation of memory B cells, and antibody profiles and investigated host factors that could contribute to vaccine responses. We found activation profiles of circulating T follicular helper type-1 cells at the early stage correlated strongly with the total change in antibody titers induced by vaccination. Formation of influenza-specific hemagglutinin-binding memory B cells was significantly higher in seroconverters compared with nonseroconverters. In-depth antibody characterization revealed a reduction in immunoglobulin G3 before and after vaccination in the Indigenous Australian population, potentially linked to the increased frequency of the G3m21* allotype. Overall, our data provide evidence that Indigenous populations elicit robust, broad, and prototypical immune responses following immunization with seasonal inactivated influenza vaccines. Our work strongly supports the recommendation of influenza vaccination to protect Indigenous populations from severe seasonal influenza virus infections and their subsequent complications. |
| اللغة: | English |
| تدمد: | 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8177d032c766c8c1ba09d40bd774890 https://doi.org/10.1073/pnas.2109388118 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f8177d032c766c8c1ba09d40bd774890 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00278424 |
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