The BioGRID interaction database: 2019 update
| العنوان: | The BioGRID interaction database: 2019 update |
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| المؤلفون: | Christie S. Chang, Jennifer M. Rust, Genie Leung, Lara O'Donnell, Andrew Chatr-aryamontri, Andrew Willems, Chris Stark, Nadine Kolas, Bobby-Joe Breitkreutz, Jasmin Coulombe-Huntington, Rochelle McAdam, Kara Dolinski, Sonam Dolma, Rose Oughtred, Frederick Zhang, Mike Tyers, Lorrie Boucher |
| المصدر: | Nucleic Acids Research |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Databases, Factual, Chemical interaction, Biology, computer.software_genre, Mice, 03 medical and health sciences, 0302 clinical medicine, Gene interaction, Drug Discovery, Protein Interaction Mapping, Controlled vocabulary, Genetics, Database Issue, Animals, Humans, Data Curation, 030304 developmental biology, 0303 health sciences, Database, Data curation, Extramural, Archival storage, Genes, CRISPR-Cas Systems, Web service, DrugBank, computer, 030217 neurology & neurosurgery |
| الوصف: | The Biological General Repository for Interaction Datasets (BioGRID: https://thebiogrid.org) is an open access database dedicated to the curation and archival storage of protein, genetic and chemical interactions for all major model organism species and humans. As of September 2018 (build 3.4.164), BioGRID contains records for 1 598 688 biological interactions manually annotated from 55 809 publications for 71 species, as classified by an updated set of controlled vocabularies for experimental detection methods. BioGRID also houses records for >700 000 post-translational modification sites. BioGRID now captures chemical interaction data, including chemical–protein interactions for human drug targets drawn from the DrugBank database and manually curated bioactive compounds reported in the literature. A new dedicated aspect of BioGRID annotates genome-wide CRISPR/Cas9-based screens that report gene–phenotype and gene–gene relationships. An extension of the BioGRID resource called the Open Repository for CRISPR Screens (ORCS) database (https://orcs.thebiogrid.org) currently contains over 500 genome-wide screens carried out in human or mouse cell lines. All data in BioGRID is made freely available without restriction, is directly downloadable in standard formats and can be readily incorporated into existing applications via our web service platforms. BioGRID data are also freely distributed through partner model organism databases and meta-databases. |
| تدمد: | 1362-4962 0305-1048 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83c4d9a85b766ead8d36c85f08ca5ac https://doi.org/10.1093/nar/gky1079 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f83c4d9a85b766ead8d36c85f08ca5ac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13624962 03051048 |
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