Circulating and disseminated tumor cells in pancreatic cancer and their role in patient prognosis: a systematic review and meta-analysis
| العنوان: | Circulating and disseminated tumor cells in pancreatic cancer and their role in patient prognosis: a systematic review and meta-analysis |
|---|---|
| المؤلفون: | Anubhav Mittal, Philip R. de Reuver, David Stephenson, Terence Chua, Christopher B. Nahm, Jaswinder S. Samra, Anthony J. Gill |
| المصدر: | Oncotarget Oncotarget, 8, 63, pp. 107223-107236 Oncotarget, 8, 107223-107236 |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, disseminated tumor cells, pancreatic cancer, Tumor cells, circulating tumor cells, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Circulating tumor cell, Internal medicine, Pancreatic cancer, medicine, business.industry, Hazard ratio, Cancer, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Meta-analysis, CA19-9, Bone marrow, prognosis, business, Meta-Analysis |
| الوصف: | // David Stephenson 1 , Christopher Nahm 1, 2 , Terence Chua 2 , Anthony Gill 1, 3 , Anubhav Mittal 1, 2 , Philip de Reuver 4 and Jaswinder Samra 1, 2 1 Sydney Medical School, University of Sydney, Camperdown, Sydney, Australia 2 Upper GI Surgical Unit, Department of Gastrointestinal Surgery, Royal North Shore Hospital, St. Leonards, Sydney, Australia 3 Cancer Diagnosis and Pathology, Kolling Institute, Royal North Shore Hospital, St. Leonards, Sydney, Australia 4 Department of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands Correspondence to: Christopher Nahm, email: chris.nahm@sydney.edu.au Keywords: circulating tumor cells, disseminated tumor cells, pancreatic cancer, prognosis Received: May 30, 2017 Accepted: July 25, 2017 Published: August 04, 2017 ABSTRACT Background: Disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) have been postulated to seed metastases and contribute to poorer patient outcomes in many types of solid cancer. To date, no systematic reviews have examined the role of both DTCs and CTCs in pancreatic cancer. We aimed to determine the prognostic value of DTCs/CTCs in pancreatic cancer using a systematic review and meta-analysis. Materials and Methods: A comprehensive literature search identified studies examining DTCs and CTCs in the bone marrow and blood of pancreatic cancer patients at diagnosis with follow-up to determine disease-free/progression-free survival (DFS/PFS) and overall survival (OS). Statistical analyses were performed to determine the hazard ratio (HR) of DTCs/CTCs on DFS/PFS and OS. Results: The literature search identified 16 articles meeting the inclusion criteria. The meta-analysis demonstrated statistically significant HR differences in DFS/PFS (HR = 1.93, 95% CI 1.19–3.11, P = 0.007) and OS (HR = 1.84, 95% CI 1.37–2.45, P =< 0.0001), indicating patients with detectable DTCs/CTCs at diagnosis have worse prognoses. Subgroup analyses suggested CTCs in the peripheral blood (HR =2.03) were more indicative of poor OS prognosis than DTCs in the bone marrow (HR = 1.91), although the difference between these was not statistically significant. Positivity of the CellSearch detection method for DTC/CTC had the highest correlation with decreased OS (HR = 2.79) while immunodetection (HR = 1.91) and RT-PCR (HR = 1.25) were less effective in determining prognosis. Conclusion: The detection of DTCs/CTCs at diagnosis is associated with poorer DFS/PFS and OS in pancreatic cancer. |
| تدمد: | 1949-2553 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bb103cbb367f5c9c56a1a90e8b2d74 https://hdl.handle.net/2066/181880 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f8bb103cbb367f5c9c56a1a90e8b2d74 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19492553 |
|---|