Effect of Amyloid-β Monomers on Lipid Membrane Mechanical Parameters–Potential Implications for Mechanically Driven Neurodegeneration in Alzheimer’s Disease
| العنوان: | Effect of Amyloid-β Monomers on Lipid Membrane Mechanical Parameters–Potential Implications for Mechanically Driven Neurodegeneration in Alzheimer’s Disease |
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| المؤلفون: | Dominik Drabik, Grzegorz Chodaczek, Sebastian Kraszewski |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 18, p 18 (2021) International Journal of Molecular Sciences Volume 22 Issue 1 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Lipid Bilayers, Membrane Potentials, Pathogenesis, lcsh:Chemistry, Molecular dynamics, 0302 clinical medicine, Lipid bilayer, lcsh:QH301-705.5, Spectroscopy, Neurons, Microscopy, Confocal, Chemistry, flicker-noise spectroscopy, Neurodegeneration, giant unilamellar vesicles, neurodegeneration, Brain, Neurodegenerative Diseases, General Medicine, pressure wave, Computer Science Applications, Membrane, medicine.anatomical_structure, Phosphatidylcholines, membrane mechanics, Molecular Dynamics Simulation, Article, Catalysis, Inorganic Chemistry, Membrane Lipids, 03 medical and health sciences, Alzheimer Disease, medicine, Humans, Physical and Theoretical Chemistry, Molecular Biology, Amyloid beta-Peptides, Mechanism (biology), Cell Membrane, Organic Chemistry, medicine.disease, Peptide Fragments, molecular dynamics, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, amyloid-beta peptides, Biophysics, Neuron, 030217 neurology & neurosurgery, Function (biology) |
| الوصف: | Alzheimer&rsquo s disease (AD) is a neurodegenerative disease that results in memory loss and the impairment of cognitive skills. Several mechanisms of AD&rsquo s pathogenesis were proposed, such as the progressive accumulation of amyloid-&beta (A&beta ) and &tau pathology. Nevertheless, the exact neurodegenerative mechanism of the A&beta remains complex and not fully understood. This paper proposes an alternative hypothesis of the mechanism based on maintaining the neuron membrane&rsquo s mechanical balance. The incorporation of A&beta decreases the lipid membrane&rsquo s elastic properties, which eventually leads to the impairment of membrane clustering, disruption of mechanical wave propagation, and change in gamma oscillations. The first two disrupt the neuron&rsquo s ability to function correctly while the last one decreases sensory encoding and perception enabling. To begin discussing this mechanical-balance hypothesis, we measured the effect of two selected peptides, A&beta 40 and A&beta 42, as well as their fluorescently labeled modification, on membrane mechanical properties. The decrease of bending rigidity, consistent for all investigated peptides, was observed using molecular dynamic studies and experimental flicker-noise techniques. Additionally, wave propagation was investigated with molecular dynamic studies in membranes with and without incorporated neurodegenerative peptides. A change in membrane behavior was observed in the membrane system with incorporated A&beta |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9040f807159ef7a6db2fd78a258d4d9 https://www.mdpi.com/1422-0067/22/1/18 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f9040f807159ef7a6db2fd78a258d4d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
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