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Irbesartan ameliorates chronic mountain sickness in a rat model via the cholesterol metabolism: An iTRAQ -based proteomics analysis

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العنوان: Irbesartan ameliorates chronic mountain sickness in a rat model via the cholesterol metabolism: An iTRAQ -based proteomics analysis
المؤلفون: Ainiwaer Aikemu, Tao Yang, Yiliyaer Nijiati, Dilinuer Maimaitiyiming, Mutalifu Aimaiti
المصدر: Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111802-(2021)
سنة النشر: 2021
مصطلحات موضوعية: 0301 basic medicine, Proteomics, medicine.medical_specialty, Pulmonary Circulation, Cholesterol Metabolism, RM1-950, Pharmacology, Altitude Sickness, Pulmonary Artery, Vascular Remodeling, ITRAQ-based proteomics, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Irbesartan, medicine.artery, Medicine, Animals, Cholesterol metabolism, Protein Interaction Maps, Antihypertensive Agents, business.industry, Therapeutic effect, General Medicine, medicine.disease, Rats, 030104 developmental biology, Chronic mountain sickness, Cholesterol, 030220 oncology & carcinogenesis, Pulmonary artery, Chronic Disease, Immunohistochemistry, Histopathology, Therapeutics. Pharmacology, business, Biomarkers, medicine.drug
الوصف: Objective: To study the effects of irbesartan on pulmonary artery lesions in a rat model with chronic mountain sickness (CMS) and identify the biomarkers involved. Methods: In this study, we used a rat model of CMS to evaluate the therapeutic effect of irbesartan by measuring pulmonary artery pressure and evaluating the histopathology of the pulmonary artery. We also used proteomics technology to identify differentially expressed proteins (DEPs) in the serum and performed bioinformatics analysis. Results were then verified by enzyme linked immunosorbent assay (ELISA) and immunohistochemistry (IHC). Results: Irbesartan treatment induced a significant decrease (P
تدمد: 1950-6007
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90c14ce622d0558c32a6a21f0e0050c
https://pubmed.ncbi.nlm.nih.gov/34147903
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....f90c14ce622d0558c32a6a21f0e0050c
قاعدة البيانات: OpenAIRE
الوصف
تدمد:19506007