‘Primed’ Mesenchymal Stem Cells: a Potential Novel Therapeutic for COVID19 Patients
| العنوان: | ‘Primed’ Mesenchymal Stem Cells: a Potential Novel Therapeutic for COVID19 Patients |
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| المؤلفون: | Mohsin Ali Khan, Syed Shadab Raza, Pankaj Seth |
| المصدر: | Stem Cell Reviews and Reports |
| بيانات النشر: | Springer US, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, COVID19, Priming (immunology), Disease, MSC priming, Bioinformatics, Mesenchymal Stem Cell Transplantation, Article, Immunomodulation, 03 medical and health sciences, 0302 clinical medicine, Pandemic, medicine, Effective treatment, Humans, Pandemics, business.industry, SARS-CoV-2, Public health, Mesenchymal stem cell, COVID-19, Coronavirus, Regimen, 030104 developmental biology, 030220 oncology & carcinogenesis, Mesenchymal stem cells, Stem cell, business |
| الوصف: | The COVID19 pandemic, designated as a public health crisis by the World Health Organization (WHO), is rapidly spreading around the world impacting the health and economy of almost all the countries. The data of hospitalized COVID19 patients, especially those with serious illness, indicate the involvement of immunopathological complications. As no effective treatment is currently available, we propose 'Primed' Mesenchymal Stem Cells (MSCs) as a therapeutic alternative to tackle devastating epidemic. The individual response to MSCs treatment is heterogeneous. During the treatment of infectious pathology, the effectiveness of the treatment may vary based on the disease scenario. Interestingly, when transplanted in vivo, MSCs are governed by the locally regulated microenvironment, suggesting that the restorative variability could be tailored by choosing a priming regimen to specifically correct a given pathology. Therefore, in our opinion, the priming of MSCs could be a novel approach to improve the responses of COVID19 patients. |
| اللغة: | English |
| تدمد: | 2629-3277 2629-3269 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f934c717e9f52ebdc0ea492ca32b2781 http://europepmc.org/articles/PMC7317273 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f934c717e9f52ebdc0ea492ca32b2781 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 26293277 26293269 |
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