LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling
| العنوان: | LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling |
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| المؤلفون: | Shuchun Li, Jing Sun, Junjun Ma, Cixiang Zhou, Xiao Yang, Sen Zhang, Ling Huang, Hongtao Jia, Yanfei Shao, Enkui Zhang, Minhua Zheng, Qian Zhao, Lu Zang |
| المصدر: | Cellular and Molecular Life Sciences. 80 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology, Cellular and Molecular Neuroscience, Stomach Neoplasms, Chromosomal Proteins, Non-Histone, Humans, Molecular Medicine, RNA, Long Noncoding, Cell Biology, Tumor Suppressor Protein p53, Molecular Biology |
| الوصف: | It has been established that long noncoding RNAs (lncRNAs) play a crucial role in various cancer types, and there are vast numbers of long noncoding RNA transcripts that have been identified by high-throughput methods. However, the biological function of many novel aberrantly expressed lncRNAs remains poorly elucidated, especially in gastric cancer (GC). Here, we first identified a novel lncRNA termed LENGA (Low Expression Noncoding RNA in Gastric Adenocarcinoma), which was significantly downregulated in GC tissues compared to adjacent normal tissues. Next, we found that reduced expression of LENGA in GC was also associated with a shorter life expectancy. The proliferation, migration, and invasion of GC cells were increased after LENGA knockdown but restrained after LENGA overexpression in vitro and in vivo. It was further demonstrated that LENGA physically binds to BRD7 (bromodomain-containing 7) in the bromodomain domain and acts as a scaffold that enhances the interaction between BRD7 and TP53 (tumor protein p53), regulating the expression of a subset of genes in the p53 pathway, including CDKN1A (cyclin-dependent kinase inhibitor 1A) and PCDH7 (protocadherin 7), at the transcriptional level. Consistently, the expression of CDKN1A has a positive correlation with LENGA in GC patients. Taken together, this study uncovers a novel tumor suppressor lncRNA, LENGA, and describes its biological function, molecular mechanism, and clinical significance. This highlights the potential importance of targeting the LENGA/BRD7/TP53 axis in GC treatment. |
| تدمد: | 1420-9071 1420-682X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94ebcd848d64fdd3315699e3042d2d1 https://doi.org/10.1007/s00018-022-04642-2 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f94ebcd848d64fdd3315699e3042d2d1 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14209071 1420682X |
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