Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators
| العنوان: | Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators |
|---|---|
| المؤلفون: | James R. Olson, Ahmed A. Ismail, Diane S. Rohlman, Gaafar M Abdel-Rasoul, Olfat Hendy, Michael R. Lasarev |
| المصدر: | Metabolic Brain Disease. 29:845-855 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Adolescent, Neuropsychological Tests, Biochemistry, Article, Toxicology, Executive Function, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Urinary levels, Occupational Exposure, Surveys and Questionnaires, Environmental health, Humans, Medicine, Working population, Attention, Pesticides, Child, business.industry, Small sample, Pesticide, TCPy, Memory, Short-Term, chemistry, Chlorpyrifos, Egypt, Female, Neurology (clinical), Occupational exposure, business, Organophosphorus pesticides |
| الوصف: | Children and adolescents may have occupational exposure to pesticides. Although previous studies examining prenatal pesticide exposure have identified neurobehavioral deficits in children, there are limited studies examining the impact of occupational exposure in children. The objectives of this study are to estimate exposures to the organophosphorus pesticide, chlorpyrifos (CPF), by measuring urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and blood cholinesterase (ChE) activities and to characterize neurobehavioral performance in adolescents working as seasonal pesticide applicators and non-applicator controls. A neurobehavioral test battery, consisting of 14 tests, was used to assess a broad range of functions. Applicators performed worse than controls on the majority of tests. Principal component analysis was used to reduce the number of outcome variables and two components, focused on reasoning-short-term memory and attention-executive functioning, showed significant deficits in applicators compared to non-applicators. Elevated metabolite levels were found in the applicators compared to the non-applicators, confirming CPF exposure in the applicators. Although this study is limited by a small sample size, it provides preliminary evidence of moderate CPF exposures, decreased blood ChE in some applicators and decreased neurobehavioral performance in an adolescent working population. |
| تدمد: | 1573-7365 0885-7490 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96618f5a70c8e25b6761e1c34b8d853 https://doi.org/10.1007/s11011-014-9565-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f96618f5a70c8e25b6761e1c34b8d853 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15737365 08857490 |
|---|