Interaction of Iron Deficiency Anemia and Hemoglobinopathies Among College Students and Pregnant Women: A Multi Center Evaluation in India
| العنوان: | Interaction of Iron Deficiency Anemia and Hemoglobinopathies Among College Students and Pregnant Women: A Multi Center Evaluation in India |
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| المؤلفون: | Jagadish Mahanta, Lata Jagannathan, Ajit Gorakshakar, Malay K. Ghosh, Reitt P. Britt, Deepak Kumar Shukla, Utpal Chaudhari, Dipika Mohanty, Ramesh Z. Patel, Vasantha Muthuswamy, Rajni Kaul, Cecil Ross, Dilip C. Master, Sheila Das, Santanu Kumar Sharma, Roshan B. Colah, Shawinder Singh |
| المصدر: | Hemoglobin. 38:252-257 |
| بيانات النشر: | Informa UK Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, Universities, Clinical Biochemistry, India, Physiology, Young Adult, chemistry.chemical_compound, Pregnancy, Prevalence, Humans, Medicine, Public Health Surveillance, Geography, Medical, Students, Genetics (clinical), Anemia, Iron-Deficiency, business.industry, RED-CELL INDICES, Biochemistry (medical), Zinc protoporphyrin, Hematology, Iron deficiency, medicine.disease, Hemoglobinopathies, chemistry, Iron-deficiency anemia, Female, West bengal, Hemoglobin, business |
| الوصف: | Although iron deficiency anemia is very common in India, systematic large studies on the prevalence and hematological consequences of iron deficiency among carriers of β-thalassemia (β-thal) and other hemoglobinopathies are lacking. A multi center project was undertaken to screen college/university students and pregnant women for iron deficiency anemia and various hemoglobinopathies. Fifty-six thousand, seven hundred and seventy-two subjects from six states, Maharashtra, Gujarat, Karnataka, West Bengal, Assam and Punjab, were studied. Iron deficiency anemia was evaluated by measuring zinc protoporphyrin (ZPP) and hemoglobin (Hb) levels, while β-thal and other hemoglobinopathies were detected by measuring the red cell indices and by Hb analysis using high performance liquid chromatography (HPLC). College boys (2.2%), college girls (14.3%) and antenatal women (27.0%) without any hemoglobinopathies had iron deficiency anemia. Among the β-thal carriers, the prevalence of iron deficiency anemia was 17.3% in college boys, 38.1% in college girls and 55.9% in pregnant women, while in the Hb E [β26(B8)Glu→Lys; HBB: c.79GA] carriers, it was 7.3% in college boys, 25.4% in college girls and 78.0% in antenatal women. In individuals with Hb E disease, the prevalence of iron deficiency anemia varied from 31.2-77.3% in the three groups. A significant reduction in Hb levels was seen when iron deficiency anemia was associated with hemoglobinopathies. However, the Hb A2 levels in β-thal carriers were not greatly reduced in the presence of iron deficiency anemia. |
| تدمد: | 1532-432X 0363-0269 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98805c1592ce8674cb37aebf057b9d2 https://doi.org/10.3109/03630269.2014.913517 |
| رقم الأكسشن: | edsair.doi.dedup.....f98805c1592ce8674cb37aebf057b9d2 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 1532432X 03630269 |
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