Efficacy of Cilostazol Administration in Alzheimer’s Disease Patients with White Matter Lesions: A Positron-Emission Tomography Study
| العنوان: | Efficacy of Cilostazol Administration in Alzheimer’s Disease Patients with White Matter Lesions: A Positron-Emission Tomography Study |
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| المؤلفون: | Yu Kyeong Kim, Eun Jin Yoon, Haewoo Lee, Hye Bin Yoo, Hee-Yeon Jung, Jun-Young Lee, Ye Ha Jung, Ho Young Lee, Jung Seok Choi, Hongrae Kim |
| المصدر: | Neurotherapeutics. 16:394-403 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Neurology, Clinical Dementia Rating, Neuropsychological Tests, Placebo, Gastroenterology, 03 medical and health sciences, Cognition, 0302 clinical medicine, Double-Blind Method, Alzheimer Disease, Internal medicine, Activities of Daily Living, medicine, Humans, Pharmacology (medical), Donepezil, Aged, Aged, 80 and over, Pharmacology, Fluorodeoxyglucose, business.industry, Brain, Repeated measures design, White Matter, Hyperintensity, Cilostazol, Glucose, Neuroprotective Agents, Treatment Outcome, 030104 developmental biology, Positron-Emission Tomography, Original Article, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | This study tested the efficacy of the phosphodiesterase type III inhibitor cilostazol in Alzheimer’s disease patients with white matter lesions treated with donepezil in comparison with donepezil monotherapy using fluorodeoxyglucose ((18)F) positron-emission tomography (FDG PET). A 24-week, randomized, double-blind, placebo-controlled, parallel-group study was conducted. Thirty-six Alzheimer’s disease patients with white matter lesions who received donepezil (n = 18 each in the cilostazol and placebo groups) were enrolled. Participants underwent pre and post FDG PET imaging scans and three rounds of clinical and neuropsychological tests. The cilostazol group did not show a significant decrease of regional glucose metabolism; however, regional glucose metabolism was significantly decreased in the parietal and frontal lobes of the placebo group. The repeated measures ANOVA measuring differences in uptake change revealed that regional glucose metabolism in the left inferior frontal gyrus was significantly more preserved in the cilostazol group than that in the placebo group (p |
| تدمد: | 1878-7479 1933-7213 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f989794ad5931bbbc30bb71941cc706f https://doi.org/10.1007/s13311-018-00708-x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f989794ad5931bbbc30bb71941cc706f |
| قاعدة البيانات: | OpenAIRE |
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Full Text via ClinicalKey | تدمد: | 18787479 19337213 |
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