The influence of ipsapirone, a 5-HT1A agonist, on sleep patterns of healthy subjects
| العنوان: | The influence of ipsapirone, a 5-HT1A agonist, on sleep patterns of healthy subjects |
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| المؤلفون: | M J Flanigan, Helen S. Driver, A J Bentley, Duncan Mitchell, H G Luus, Colin M. Shapiro |
| المصدر: | Psychopharmacology. 117:186-192 |
| بيانات النشر: | Springer Science and Business Media LLC, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Adult, Male, Pharmacology, Agonist, Cross-Over Studies, medicine.drug_class, Polysomnography, Ipsapirone, Sleep, REM, Placebo, Crossover study, Sleep in non-human animals, Serotonin Receptor Agonists, Pyrimidines, Double-Blind Method, Oral administration, Anesthesia, medicine, Humans, Female, Serotonin, Sleep, Psychology, medicine.drug, Slow-wave sleep |
| الوصف: | Ipsapirone is a new pyrimidinylpiperazine ligand specific for 5-HT1A receptors, with potential therapeutic use in affective disorders. Because 5-HT is involved in the regulation of sleep, we investigated the effect of ipsapirone hydrochloride on sleep patterns in 18 normal, healthy subjects of both sexes. Compared to placebo, ipsapirone 5 mg administered by mouth three times daily for 14 days decreased rapid eye movement (REM) sleep duration and, by the tenth day of treatment, began to reduce slow wave sleep (SWS) duration. The decrease in REM sleep occurred in the first 3 h of sleep. The latency to REM sleep was increased from the first night following ipsapirone administration, remained increased throughout the 14 days of administration, and fell to equal latency on placebo immediately administration ended. Subjective assessments of sleep revealed no differences between ipsapirone and placebo. Our experiments confirm a role of 5-HT1A receptors in sleep. The effects of ipsapirone on the sleep patterns of patients with affective disorders still need to be determined. |
| تدمد: | 1432-2072 0033-3158 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a9d00c69a05291a3a935f296587750 https://doi.org/10.1007/bf02245186 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....f9a9d00c69a05291a3a935f296587750 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14322072 00333158 |
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