Characterization of a multi-pinhole molecular breast tomosynthesis scanner
| العنوان: | Characterization of a multi-pinhole molecular breast tomosynthesis scanner |
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| المؤلفون: | J. Huizenga, Freek J. Beekman, Beien Wang, Jarno van Roosmalen, Marlies C Goorden, R. Kreuger |
| المصدر: | Physics in Medicine and Biology, 65(19) |
| بيانات النشر: | IOP Publishing, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Scanner, Pinhole collimator, Breast imaging, Imaging phantom, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, Optics, law, Humans, Gamma Cameras, Radiology, Nuclear Medicine and imaging, Breast, Radionuclide Imaging, Gamma camera, Image resolution, Tomography, Emission-Computed, Single-Photon, Physics, Radiological and Ultrasound Technology, Phantoms, Imaging, business.industry, Detector, Collimator, SPECT, 030220 oncology & carcinogenesis, Female, Pinhole (optics), Radiopharmaceuticals, business |
| الوصف: | In recent years, breast imaging using radiolabelled molecules has attracted significant interest. Our group has proposed a multi-pinhole molecular breast tomosynthesis (MP-MBT) scanner to obtain 3D functional molecular breast images at high resolutions. After conducting extensive optimisation studies using simulations, we here present a first prototype of MP-MBT and evaluate its performance using physical phantoms. The MP-MBT design is based on two opposing gamma cameras that can image a lightly compressed pendant breast. Each gamma camera consists of a 250 × 150 mm2 detector equipped with a collimator with multiple pinholes focusing on a line. The NaI(Tl) gamma detector is a customised design with 3.5 mm intrinsic spatial resolution and high spatial linearity near the edges due to a novel light-guide geometry and the use of square PMTs. A volume-of-interest is scanned by translating the collimator and gamma detector together in a sequence that optimises count yield from the scan region. Derenzo phantom images showed that the system can reach 3.5 mm resolution for a clinically realistic 99mTc activity concentration in an 11-minute scan, while in breast phantoms the smallest spheres visible were 6 mm in diameter for the same scan time. To conclude, the experimental results of the novel MP-MBT scanner showed that the setup had sub-centimetre breast tumour detection capability which might facilitate 3D molecular breast cancer imaging in the future. |
| وصف الملف: | application/pdf |
| تدمد: | 1361-6560 0031-9155 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9aeb76fd1b1290ed2b4e97ec2cf1de8 https://doi.org/10.1088/1361-6560/ab9eff |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....f9aeb76fd1b1290ed2b4e97ec2cf1de8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13616560 00319155 |
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